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Comparative Subchronic Toxicity Studies of Three Disinfectants
In separate subchronic toxicity studies, male and female Sprague–Dawley rats received various dosages of chlorine, monochloramine, or chlorine dioxide in their drinking water for 90 consecutive days. None of the disinfectants caused premature death at any of the concentrations used. The highest dose of chlorine tested (250 mg/L) was concluded to be a no observable adverse effect level. At 200 mg/L (the lowest observable adverse effect level), monochloramine produced decreased body and organ weights in both sexes and a small decrease in red blood cell count and serum calcium in males. Chlorine dioxide produced dosage‐related decreases in body and organ weight at concentrations as low as 25 mg/L, but its most significant toxic effect was the induction, at all concentrations, of nasal lesions.
Comparative Subchronic Toxicity Studies of Three Disinfectants
In separate subchronic toxicity studies, male and female Sprague–Dawley rats received various dosages of chlorine, monochloramine, or chlorine dioxide in their drinking water for 90 consecutive days. None of the disinfectants caused premature death at any of the concentrations used. The highest dose of chlorine tested (250 mg/L) was concluded to be a no observable adverse effect level. At 200 mg/L (the lowest observable adverse effect level), monochloramine produced decreased body and organ weights in both sexes and a small decrease in red blood cell count and serum calcium in males. Chlorine dioxide produced dosage‐related decreases in body and organ weight at concentrations as low as 25 mg/L, but its most significant toxic effect was the induction, at all concentrations, of nasal lesions.
Comparative Subchronic Toxicity Studies of Three Disinfectants
Daniel, F. Bernard (author) / Condie, Lyman W. (author) / Robinson, Merrel (author) / Stober, Judy A. (author) / York, Raymond G. (author) / Olson, Greg R. (author) / Wang, Shin‐Ru (author)
Journal ‐ American Water Works Association ; 82 ; 61-69
1990-10-01
9 pages
Article (Journal)
Electronic Resource
English
Comparative study of disinfectants for water supply
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Comparative study of disinfectants for water supply
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Engineering Index Backfile | 1938
Engineering Index Backfile | 1938