A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Novel, Rotary Oscillated, Scalable Single‐Use Bioreactor Technology for the Cultivation of Animal Cells
The BaySHAKE® single‐use bioreactor is based on the motion principle of rotary oscillation of a polyhedral container. This fundamental working principle facilitates mixing and oxygen transfer to animal cell cultures in a simple, robust and cost‐efficient single‐use system without internal moving parts. In‐depth hydrodynamic characterization shows that the bioreactor provides mixing and oxygen transfer in a low‐shear environment over a range of scales up to several cubic meters. A biological comparison of novel single‐use technology in scales from 50 to 1000 L with the re‐usable standard deep‐tank technology in scales from 10 to 200 L confirms the technical feasibility and shows good biological equivalence for the production of monoclonal antibodies by CHO cells.
Novel, Rotary Oscillated, Scalable Single‐Use Bioreactor Technology for the Cultivation of Animal Cells
The BaySHAKE® single‐use bioreactor is based on the motion principle of rotary oscillation of a polyhedral container. This fundamental working principle facilitates mixing and oxygen transfer to animal cell cultures in a simple, robust and cost‐efficient single‐use system without internal moving parts. In‐depth hydrodynamic characterization shows that the bioreactor provides mixing and oxygen transfer in a low‐shear environment over a range of scales up to several cubic meters. A biological comparison of novel single‐use technology in scales from 50 to 1000 L with the re‐usable standard deep‐tank technology in scales from 10 to 200 L confirms the technical feasibility and shows good biological equivalence for the production of monoclonal antibodies by CHO cells.
Novel, Rotary Oscillated, Scalable Single‐Use Bioreactor Technology for the Cultivation of Animal Cells
Kauling, Jörg (author) / Brod, Helmut (author) / Jenne, Marc (author) / Waldhelm, Annette (author) / Langer, Uwe (author) / Bödeker, Berthold (author)
Chemie Ingenieur Technik ; 85 ; 127-135
2013-02-01
9 pages
Article (Journal)
Electronic Resource
English
Hydrodynamic coefficients of a harmonically oscillated tower
| Elsevier | 1983
Transient response of oscillated carbon nanotubes with an internal and external damping
| British Library Online Contents | 2019
NO Reduction and High Efficiency Combustion by Externally Oscillated Staging Burner
| British Library Online Contents | 2009
Analytical and Reynolds stress transport model results for periodically oscillated turbulent flows
| British Library Online Contents | 2004
A Self‐Oscillated Organic Synapse for In‐Memory Two‐Factor Authentication
| Wiley | 2024