A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Protective effects of valproic acid on 6‐hydroxydopamine‐induced neuroinjury
Oxidative stress may play critically important roles in the etiology of Parkinson's disease (PD). 6‐Hydroxydopamine (6‐OHDA) is a physiological neurotoxin reported to induce oxidative‐induced apoptosis of dopaminergic neurons in PD mice models. Valproic acid (VPA), a clinical mood stabilizer, is a HDAC inhibitor with neuroprotective capacities. In the study, we aim at examining the feasibility of VPA as a protector for dopaminergic neurons against damage from 6‐OHDA, and the intracellular mechanisms. The 6‐OHDA‐induced neurotoxicity to the human dopaminergic cell line SH‐SY5Y was applied for examining VPA protective effects. Pretreatment with VPA was able to improve cell viability and reduce 6‐OHDA‐induced reactive oxygen species. Furthermore, a significant suppression of apoptotic caspases including cleaved caspase‐3, caspase‐7, and caspase‐9 was observed. The results also revealed VPA decreased the 6‐OHDA‐induced Bax/Bcl2 ratio, as measured at protein level. These novel findings indicate that VPA may be capable of protecting the SH‐SY5Y dopaminergic neuronal cells from 6‐OHDA‐induced toxicity via the deceasing of apoptotic caspases (cleaved caspase‐3, caspase‐7, and caspase‐9) and reducing of the Bax/Bcl2 ratio. Very possibly, VPA could serve as not only a mood stabilizer but also a potential antidote for PD prevention.
Protective effects of valproic acid on 6‐hydroxydopamine‐induced neuroinjury
Oxidative stress may play critically important roles in the etiology of Parkinson's disease (PD). 6‐Hydroxydopamine (6‐OHDA) is a physiological neurotoxin reported to induce oxidative‐induced apoptosis of dopaminergic neurons in PD mice models. Valproic acid (VPA), a clinical mood stabilizer, is a HDAC inhibitor with neuroprotective capacities. In the study, we aim at examining the feasibility of VPA as a protector for dopaminergic neurons against damage from 6‐OHDA, and the intracellular mechanisms. The 6‐OHDA‐induced neurotoxicity to the human dopaminergic cell line SH‐SY5Y was applied for examining VPA protective effects. Pretreatment with VPA was able to improve cell viability and reduce 6‐OHDA‐induced reactive oxygen species. Furthermore, a significant suppression of apoptotic caspases including cleaved caspase‐3, caspase‐7, and caspase‐9 was observed. The results also revealed VPA decreased the 6‐OHDA‐induced Bax/Bcl2 ratio, as measured at protein level. These novel findings indicate that VPA may be capable of protecting the SH‐SY5Y dopaminergic neuronal cells from 6‐OHDA‐induced toxicity via the deceasing of apoptotic caspases (cleaved caspase‐3, caspase‐7, and caspase‐9) and reducing of the Bax/Bcl2 ratio. Very possibly, VPA could serve as not only a mood stabilizer but also a potential antidote for PD prevention.
Protective effects of valproic acid on 6‐hydroxydopamine‐induced neuroinjury
Hsu, Shih‐Wei (author) / Hsu, Pei‐Chen (author) / Chang, Wen‐Shin (author) / Yu, Chien‐Chih (author) / Wang, Yun‐Chi (author) / Yang, Jai‐Sing (author) / Tsai, Fuu‐Jen (author) / Chen, Kai‐Yuan (author) / Tsai, Chia‐Wen (author) / Bau, Da‐Tian (author)
Environmental Toxicology ; 35 ; 840-848
2020-08-01
9 pages
Article (Journal)
Electronic Resource
English
Synthesis of new N-glycosides based on Valproic acid analogs tetrazole derivatives
| British Library Online Contents | 2017
Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid
| DOAJ | 2024
An in vitro controlled release study of valproic acid encapsulated in a titania ceramic matrix
| British Library Online Contents | 2011
British Library Online Contents | 2017