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Smart Scaffold Constructs for Regenerative Medicine and Tissue Engineering
Tissue engineering represents a prominent tool in regenerative medicine and has been an active domain of scientific research for the last few decades. It is an alluring approach to restore, retain, and revitalize lost or damaged tissues and organs by combining the understanding and inventions from developmental biology, stem cells, and materials science. Basically, the approach incorporates three significant modules: (i) a scaffold that creates a microenvironment facilitating cell adhesion for tissue development; (ii) a suitable cell type; and (iii) biomolecules that direct cell behavior and function. With the advancement of new technologies and novel therapeutic agents, smart approaches like the development of smart scaffolds to deliver the requirements in an efficient and controllable manner become inevitable. Smart scaffolds seek to imitate the dynamic behavior of native extracellular matrix of tissues. The multi‐functionality and smartness of the material enable them to execute multiple crucial tasks simultaneously, viz., delivery of essential bioactive agents, cell growth regulation, differentiation, and direct stem cell functioning. In this chapter, the characteristics and significance of such scaffold constructs will be discussed, focusing on the different application areas of regenerative medicine like bone, muscle, skin, cardiovascular, and neural tissue engineering along with recent efforts through techniques in improving efficiency, controlling the smartness of the scaffolds, and translating the in vitro smartness to successful in vivo tissue repair and regeneration.
Smart Scaffold Constructs for Regenerative Medicine and Tissue Engineering
Tissue engineering represents a prominent tool in regenerative medicine and has been an active domain of scientific research for the last few decades. It is an alluring approach to restore, retain, and revitalize lost or damaged tissues and organs by combining the understanding and inventions from developmental biology, stem cells, and materials science. Basically, the approach incorporates three significant modules: (i) a scaffold that creates a microenvironment facilitating cell adhesion for tissue development; (ii) a suitable cell type; and (iii) biomolecules that direct cell behavior and function. With the advancement of new technologies and novel therapeutic agents, smart approaches like the development of smart scaffolds to deliver the requirements in an efficient and controllable manner become inevitable. Smart scaffolds seek to imitate the dynamic behavior of native extracellular matrix of tissues. The multi‐functionality and smartness of the material enable them to execute multiple crucial tasks simultaneously, viz., delivery of essential bioactive agents, cell growth regulation, differentiation, and direct stem cell functioning. In this chapter, the characteristics and significance of such scaffold constructs will be discussed, focusing on the different application areas of regenerative medicine like bone, muscle, skin, cardiovascular, and neural tissue engineering along with recent efforts through techniques in improving efficiency, controlling the smartness of the scaffolds, and translating the in vitro smartness to successful in vivo tissue repair and regeneration.
Smart Scaffold Constructs for Regenerative Medicine and Tissue Engineering
Kumar, Upendra (editor) / Sonkar, Piyush Kumar (editor) / Choudhary, Princy (author) / Gupta, Ayushi (author) / Gupta, Saurabh Kumar (author) / Dwivedi, Shrey (author) / Singh, Sangeeta (author)
2024-05-17
35 pages
Article/Chapter (Book)
Electronic Resource
English
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