A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Moving Horizon Parameter Estimation for an Enzyme‐Catalyzed Transamination Reaction with Integrated Product Removal
Chiral amines are key building blocks in producing active pharmaceutical ingredients and can be synthesized via the amine transaminase pathway under mild conditions with eco‐friendly solvents. For model‐based design and control, mathematical models can be utilized. This requires reliable parameterization of the model. In this study, a model for the production of (S)‐(3 methoxyphenyl)‐ethylamine is presented. Parameter identifiability is analyzed using the method of profile likelihoods. The parameter identifiability is then tested in two different batch operation scenarios by using moving horizon estimation, which can be applied for on‐line model adaption and control purposes. In a batch process, identifiability decreases over time. A repetitive batch strategy improves parameter identifiability.
Moving Horizon Parameter Estimation for an Enzyme‐Catalyzed Transamination Reaction with Integrated Product Removal
Chiral amines are key building blocks in producing active pharmaceutical ingredients and can be synthesized via the amine transaminase pathway under mild conditions with eco‐friendly solvents. For model‐based design and control, mathematical models can be utilized. This requires reliable parameterization of the model. In this study, a model for the production of (S)‐(3 methoxyphenyl)‐ethylamine is presented. Parameter identifiability is analyzed using the method of profile likelihoods. The parameter identifiability is then tested in two different batch operation scenarios by using moving horizon estimation, which can be applied for on‐line model adaption and control purposes. In a batch process, identifiability decreases over time. A repetitive batch strategy improves parameter identifiability.
Moving Horizon Parameter Estimation for an Enzyme‐Catalyzed Transamination Reaction with Integrated Product Removal
Behrens, Jessica (author) / Tiedemann, Sven (author) / Kunde, Tom (author) / von Langermann, Jan (author) / Kienle, Achim (author)
Chemie Ingenieur Technik ; 96 ; 1751-1766
2024-12-01
16 pages
Article (Journal)
Electronic Resource
English
Transamination of α-amino nitriles
| British Library Online Contents | 2014
Moving Horizon Model Inversion for Nonlinear ILC
| British Library Online Contents | 2011
Offset-Free Model Predictive Control of an Open Water Channel Based on Moving Horizon Estimation
| British Library Online Contents | 2017
Moving horizon estimation for assimilating H-SAF remote sensing data into the HBV hydrological model
| British Library Online Contents | 2016
Moving horizon estimation for assimilating H-SAF remote sensing data into the HBV hydrological model
| British Library Online Contents | 2016