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A platform for research: civil engineering, architecture and urbanism
Co‐exposure of iron oxide nanoparticles and glyphosate‐based herbicide promote liver toxicity in guppy (Poecilia reticulata): A histochemical and ultrastructural approach
Citrate functionalized iron oxide nanoparticles (IONPs) are employed for various purposes‐including environmental remediation but the interaction of IONPs with aquatic contaminants is poorly understood. Among those, glyphosate‐based herbicides are toxic and affect target organs such as the liver. Evaluations of livers of female Poecilia reticulata by exposures to IONPs at a concentration of 0.3 mg/L were performed with association to: (1) 0.65 mg of glyphosate per litter and (2) 1.3 mg of glyphosate per litter of Roundup Original, and (3) glyphosate P.A at 0.65 mg/L. These associations were carried out progressively, after 7, 14, and 21 days. We detected circulatory disturbances, inflammatory responses, activation of the immune system, regressive changes, and progressive responses with changes in the connective tissue and decreased glycogen reserve from days 14 to 21. Ultrastructural changes in the Disse space and microvilli of hepatocytes indicated decreased contact surface area. In general, the damage was time and concentration dependent, increasing from 7 to 14 days and tending to stabilize from 14 to 21 days. Therefore, herbicide‐associated IONPs functioned as xenobiotics inducing intense cellular detoxification processes and activation of hepatic immune responses.
Co‐exposure of iron oxide nanoparticles and glyphosate‐based herbicide promote liver toxicity in guppy (Poecilia reticulata): A histochemical and ultrastructural approach
Citrate functionalized iron oxide nanoparticles (IONPs) are employed for various purposes‐including environmental remediation but the interaction of IONPs with aquatic contaminants is poorly understood. Among those, glyphosate‐based herbicides are toxic and affect target organs such as the liver. Evaluations of livers of female Poecilia reticulata by exposures to IONPs at a concentration of 0.3 mg/L were performed with association to: (1) 0.65 mg of glyphosate per litter and (2) 1.3 mg of glyphosate per litter of Roundup Original, and (3) glyphosate P.A at 0.65 mg/L. These associations were carried out progressively, after 7, 14, and 21 days. We detected circulatory disturbances, inflammatory responses, activation of the immune system, regressive changes, and progressive responses with changes in the connective tissue and decreased glycogen reserve from days 14 to 21. Ultrastructural changes in the Disse space and microvilli of hepatocytes indicated decreased contact surface area. In general, the damage was time and concentration dependent, increasing from 7 to 14 days and tending to stabilize from 14 to 21 days. Therefore, herbicide‐associated IONPs functioned as xenobiotics inducing intense cellular detoxification processes and activation of hepatic immune responses.
Co‐exposure of iron oxide nanoparticles and glyphosate‐based herbicide promote liver toxicity in guppy (Poecilia reticulata): A histochemical and ultrastructural approach
Martins, Lunara Kênida Lessa (author) / Lima‐Faria, João Marcos de (author) / Guimarães, Lucas Nunes (author) / Silva, Victória Costa da (author) / Moreira, Paulo Cesar (author) / Sabóia‐Morais, Simone Maria Teixeira de (author)
Environmental Toxicology ; 37 ; 2244-2258
2022-09-01
15 pages
Article (Journal)
Electronic Resource
English
Effect of nonylphenol on plasma vitellogenin of male adult guppies (Poecilia reticulata)
| Online Contents | 2005