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Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Krüger, Franziska (author) / Kumar, Vipin (author) / Monge, Pere (author) / Conzelmann, Carina (author) / Smith, Nikaïa (author) / Gothelf, Kurt V. (author) / Tolstrup, Martin (author) / Münch, Jan (author) / Zelikin, Alexander N. (author)
Advanced Science ; 6
2019-03-01
5 pages
Article (Journal)
Electronic Resource
English
| British Library Online Contents | 2012
| British Library Online Contents | 2017
| British Library Online Contents | 2017