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Life‐history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine
10.1002/tox.20171.abs
The effects of the antiepileptic, analgesic drug carbamazepine on the growth, morphology, and life‐history characteristics of Daphnia pulex were examined at nominal concentrations of 0, 0.1, 1, 10, 100, and 200 μg L−1. At 1 μg carbamazepine L−1, Daphnia matured and reproduced slightly earlier than did controls, and at a given body length females produced more offspring than did controls or those receiving other treatments. In combination with a relatively high juvenile somatic growth rate and highest total number of progeny produced per female, carbamazepine at 1 μg L−1 seemed to exert a stimulatory effect. The rates of population growth of the 100 and 200 μg L−1 treatment groups was 9% and 32% lower, respectively, than the rates of growth of the controls and the Daphnia receiving treatments of up to 10 μg carbamazepine L−1. At the highest dose, retardation of juvenile somatic growth resulted in delayed maturity and consequently in a lower rate of population growth. Adult somatic growth, spine length, reproductive output, and size of newborns were similar among treatments. Male offspring were only produced in the third broods, with broods that were 8% and 28% male at 1 and 10 μg L−1, respectively. Neck teeth were never observed in Daphnia. Chronic adverse effects of carbamazepine on nontarget Daphnia were detected at 200 μg carbamazepine L−1, but stimulatory effects might occur at environmentally realistic concentrations. However, additional studies of chronic toxicity investigating various combinations of pharmaceuticals and various environmental stresses, such as food condition, temperature, and kairomones, are needed to fully explore potential long‐term adverse effects and to assess the environmental risk of common pharmaceuticals. © 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 172–180, 2006.
Life‐history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine
10.1002/tox.20171.abs
The effects of the antiepileptic, analgesic drug carbamazepine on the growth, morphology, and life‐history characteristics of Daphnia pulex were examined at nominal concentrations of 0, 0.1, 1, 10, 100, and 200 μg L−1. At 1 μg carbamazepine L−1, Daphnia matured and reproduced slightly earlier than did controls, and at a given body length females produced more offspring than did controls or those receiving other treatments. In combination with a relatively high juvenile somatic growth rate and highest total number of progeny produced per female, carbamazepine at 1 μg L−1 seemed to exert a stimulatory effect. The rates of population growth of the 100 and 200 μg L−1 treatment groups was 9% and 32% lower, respectively, than the rates of growth of the controls and the Daphnia receiving treatments of up to 10 μg carbamazepine L−1. At the highest dose, retardation of juvenile somatic growth resulted in delayed maturity and consequently in a lower rate of population growth. Adult somatic growth, spine length, reproductive output, and size of newborns were similar among treatments. Male offspring were only produced in the third broods, with broods that were 8% and 28% male at 1 and 10 μg L−1, respectively. Neck teeth were never observed in Daphnia. Chronic adverse effects of carbamazepine on nontarget Daphnia were detected at 200 μg carbamazepine L−1, but stimulatory effects might occur at environmentally realistic concentrations. However, additional studies of chronic toxicity investigating various combinations of pharmaceuticals and various environmental stresses, such as food condition, temperature, and kairomones, are needed to fully explore potential long‐term adverse effects and to assess the environmental risk of common pharmaceuticals. © 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 172–180, 2006.
Life‐history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine
Lürling, M. (author) / Sargant, E. (author) / Roessink, I. (author)
Environmental Toxicology ; 21 ; 172-180
2006-04-01
9 pages
Article (Journal)
Electronic Resource
English
Life-history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine
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