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A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions
Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye.
A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions
Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye.
A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions
Strakosas, Xenofon (author) / Selberg, John (author) / Zhang, Xiaolin (author) / Christie, Noah (author) / Hsu, Peng‐Hao (author) / Almutairi, Adah (author) / Rolandi, Marco (author)
Advanced Science ; 6
2019-04-01
7 pages
Article (Journal)
Electronic Resource
English
protons , bioelectronics , pH
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