A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry
10.1002/tox.20295.abs
Methyl tert‐butyl ether (MTBE) is a currently worldwide used octane enhancer substituting for lead alkyls and gasoline oxygenate. Our previous study using doubly 14C‐labeled MTBE [(CH3)314CO14CH3] has shown that MTBE binds DNA to form DNA adducts at low dose levels in mice. To elucidate the mechanism of the binding reaction, in this study, the DNA adducts with singly 14C‐labeled MTBE, which was synthesized from 14C‐methanol and tert‐butyl alcohol (TBA), or 14C‐labeled TBA in mice have been measured by ultra sensitive accelerator mass spectrometry. The results show that the methyl group of MTBE and tert‐butyl alcohol definitely form adducts with DNA in mouse liver, lung, and kidney. The methyl group of MTBE is the predominant binding part in liver, while the methyl group and the tert‐butyl group give comparable contributions to the adduct formation in lung and kidney. © 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 630–635, 2007.
Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry
10.1002/tox.20295.abs
Methyl tert‐butyl ether (MTBE) is a currently worldwide used octane enhancer substituting for lead alkyls and gasoline oxygenate. Our previous study using doubly 14C‐labeled MTBE [(CH3)314CO14CH3] has shown that MTBE binds DNA to form DNA adducts at low dose levels in mice. To elucidate the mechanism of the binding reaction, in this study, the DNA adducts with singly 14C‐labeled MTBE, which was synthesized from 14C‐methanol and tert‐butyl alcohol (TBA), or 14C‐labeled TBA in mice have been measured by ultra sensitive accelerator mass spectrometry. The results show that the methyl group of MTBE and tert‐butyl alcohol definitely form adducts with DNA in mouse liver, lung, and kidney. The methyl group of MTBE is the predominant binding part in liver, while the methyl group and the tert‐butyl group give comparable contributions to the adduct formation in lung and kidney. © 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 630–635, 2007.
Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry
Yuan, Y. (author) / Wang, H. F. (author) / Sun, H. F. (author) / Du, H. F. (author) / Xu, L. H. (author) / Liu, Y. F. (author) / Ding, X. F. (author) / Fu, D. P. (author) / Liu, K. X. (author)
Environmental Toxicology ; 22 ; 630-635
2007-12-01
6 pages
Article (Journal)
Electronic Resource
English
Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry
| Online Contents | 2007
Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry
| Online Contents | 2005
Lifting scaffold structure for building adduction structure
| European Patent Office | 2023
Use of pilot beams in accelerator mass spectrometry
| TIBKAT | 1990