A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Acidic Osteoid Templates the Plywood Structure of Bone Tissue
Bone is created by osteoblasts that secrete osteoid after which an ordered texture emerges, followed by mineralization. Plywood geometries are a hallmark of many trabecular and cortical bones, yet the origin of this texturing in vivo has never been shown. Nevertheless, extensive in vitro work revealed how plywood textures of fibrils can emerge from acidic molecular cholesteric collagen mesophases. This study demonstrates in sheep, which is the preferred model for skeletal orthopaedic research, that the deeper non‐fibrillar osteoid is organized in a liquid‐crystal cholesteric geometry. This basophilic domain, rich in acidic glycosaminoglycans, exhibits low pH which presumably fosters mesoscale collagen molecule ordering in vivo. The results suggest that the collagen fibril motif of twisted plywood matures slowly through self‐assembly thermodynamically driven processes as proposed by the Bouligand theory of biological analogues of liquid crystals. Understanding the steps of collagen patterning in osteoid‐maturation processes may shed new light on bone pathologies that emerge from collagen physico‐chemical maturation imbalances.
Acidic Osteoid Templates the Plywood Structure of Bone Tissue
Bone is created by osteoblasts that secrete osteoid after which an ordered texture emerges, followed by mineralization. Plywood geometries are a hallmark of many trabecular and cortical bones, yet the origin of this texturing in vivo has never been shown. Nevertheless, extensive in vitro work revealed how plywood textures of fibrils can emerge from acidic molecular cholesteric collagen mesophases. This study demonstrates in sheep, which is the preferred model for skeletal orthopaedic research, that the deeper non‐fibrillar osteoid is organized in a liquid‐crystal cholesteric geometry. This basophilic domain, rich in acidic glycosaminoglycans, exhibits low pH which presumably fosters mesoscale collagen molecule ordering in vivo. The results suggest that the collagen fibril motif of twisted plywood matures slowly through self‐assembly thermodynamically driven processes as proposed by the Bouligand theory of biological analogues of liquid crystals. Understanding the steps of collagen patterning in osteoid‐maturation processes may shed new light on bone pathologies that emerge from collagen physico‐chemical maturation imbalances.
Acidic Osteoid Templates the Plywood Structure of Bone Tissue
Robin, Marc (author) / Djediat, Chakib (author) / Bardouil, Arnaud (author) / Baccile, Niki (author) / Chareyron, Camille (author) / Zizak, Ivo (author) / Fratzl, Peter (author) / Selmane, Mohamed (author) / Haye, Bernard (author) / Genois, Isabelle (author)
Advanced Science ; 11
2024-03-01
14 pages
Article (Journal)
Electronic Resource
English
acidity , biomineralization , bone , collagen , liquid‐crystal , osteoid , plywood
The Research Development of Plywood Building Templates
| Trans Tech Publications | 2012
The Research Development of Plywood Building Templates
| British Library Conference Proceedings | 2012
British Library Online Contents | 1994