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Effect of acute hexavalent chromium exposure on pituitary–thyroid axis of a freshwater fish, Channa punctatus (Bloch)
Acute exposure to hexavalent chromium (10 mg L−1, 20 mg L−1, and 40 mg L−1 potassium dichromate for 96 h) dose‐dependently affected the pituitary–thyroid axis of teleost, Channa punctatus. Significant hypertrophy of the thyroid follicle was observed in 20 mg L−1 and 40 mg L−1 groups; the follicular epithelium was however hypertrophied only in 40 mg L−1 group. The colloid depletion in the lumen of thyroid follicle was evident in 20 mg L−1 and 40 mg L−1 groups. Serum thyroid hormones (thyroxine/T4 and triiodothyronine/T3) level increased significantly at both the higher doses. Increased immunointensity and significant hypertrophy of the pituitary thyrotrophs (anti TSHβ‐immunoreactive cells) was observed in both 20 mg L−1 and 40 mg L−1 chromium‐exposed fish. The increased thyroid hormones secretion observed in this study might be an adaptive response of the pituitary–thyroid axis under acute chromium‐induced stress condition to maintain homeostasis. The long‐term Cr(VI) exposures, however, may lead to attenuation/exhaustion of the pituitary–thyroid axis and pose serious threat to fish health and affect their population. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 621–627, 2015.
Effect of acute hexavalent chromium exposure on pituitary–thyroid axis of a freshwater fish, Channa punctatus (Bloch)
Acute exposure to hexavalent chromium (10 mg L−1, 20 mg L−1, and 40 mg L−1 potassium dichromate for 96 h) dose‐dependently affected the pituitary–thyroid axis of teleost, Channa punctatus. Significant hypertrophy of the thyroid follicle was observed in 20 mg L−1 and 40 mg L−1 groups; the follicular epithelium was however hypertrophied only in 40 mg L−1 group. The colloid depletion in the lumen of thyroid follicle was evident in 20 mg L−1 and 40 mg L−1 groups. Serum thyroid hormones (thyroxine/T4 and triiodothyronine/T3) level increased significantly at both the higher doses. Increased immunointensity and significant hypertrophy of the pituitary thyrotrophs (anti TSHβ‐immunoreactive cells) was observed in both 20 mg L−1 and 40 mg L−1 chromium‐exposed fish. The increased thyroid hormones secretion observed in this study might be an adaptive response of the pituitary–thyroid axis under acute chromium‐induced stress condition to maintain homeostasis. The long‐term Cr(VI) exposures, however, may lead to attenuation/exhaustion of the pituitary–thyroid axis and pose serious threat to fish health and affect their population. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 621–627, 2015.
Effect of acute hexavalent chromium exposure on pituitary–thyroid axis of a freshwater fish, Channa punctatus (Bloch)
Mishra, Ashish K. (author) / Mohanty, Banalata (author)
Environmental Toxicology ; 30 ; 621-627
2015-05-06
7 pages
Article (Journal)
Electronic Resource
English