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A platform for research: civil engineering, architecture and urbanism
Simplified, High Drug‐Loaded Formulations Containing Hydrochlorothiazide for Twin‐Screw Granulation
Simplified, high drug loaded formulations for use in twin‐screw granulation and tableting were introduced, using the plastically deforming drug ibuprofen. This concept was enlarged by application of hydrochlorothiazide, because opposed deformation behavior was expected to result in different product performances. In most instances the results differed. Critical quality attributes like granule size distribution, disintegration time, and tensile strength of tablets could be met. The study confirms the suitability of simplified formulation with differently behaving drugs for pharmaceutical product design in continuous manufacturing.
Simplified, High Drug‐Loaded Formulations Containing Hydrochlorothiazide for Twin‐Screw Granulation
Simplified, high drug loaded formulations for use in twin‐screw granulation and tableting were introduced, using the plastically deforming drug ibuprofen. This concept was enlarged by application of hydrochlorothiazide, because opposed deformation behavior was expected to result in different product performances. In most instances the results differed. Critical quality attributes like granule size distribution, disintegration time, and tensile strength of tablets could be met. The study confirms the suitability of simplified formulation with differently behaving drugs for pharmaceutical product design in continuous manufacturing.
Simplified, High Drug‐Loaded Formulations Containing Hydrochlorothiazide for Twin‐Screw Granulation
Meier, Robin (author) / Moll, Klaus‐Peter (author) / Krumme, Markus (author) / Kleinebudde, Peter (author)
Chemie Ingenieur Technik ; 89 ; 1025-1033
2017-08-01
9 pages
Article (Journal)
Electronic Resource
English
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