A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Ligand Relay Catalysis Enables Asymmetric Migratory Hydroarylation for the Concise Synthesis of Chiral α‐(Hetero)Aryl‐Substituted Amines
Complementary to the design of a single structurally complex chiral ligand to promote each step in transition‐metal catalysis, multiligand relay catalysis through dynamic ligand exchange with each step in the catalytic cycle promoted by its best ligand provides an attractive approach to enhance the whole reaction reactivity and selectivity. Herein, a regio‐ and enantioselective NiH‐catalyzed migratory hydroarylation process with a simple combination of a chain‐walking ligand and an asymmetric arylation ligand, producing high‐value chiral α‐(hetero)aryl‐substituted amines and their derivatives under mild conditions, is reported. The potential synthetic applications of this transformation are demonstrated by the concise synthesis of (S)‐nicotine and a CDK8 inhibitor.
Ligand Relay Catalysis Enables Asymmetric Migratory Hydroarylation for the Concise Synthesis of Chiral α‐(Hetero)Aryl‐Substituted Amines
Complementary to the design of a single structurally complex chiral ligand to promote each step in transition‐metal catalysis, multiligand relay catalysis through dynamic ligand exchange with each step in the catalytic cycle promoted by its best ligand provides an attractive approach to enhance the whole reaction reactivity and selectivity. Herein, a regio‐ and enantioselective NiH‐catalyzed migratory hydroarylation process with a simple combination of a chain‐walking ligand and an asymmetric arylation ligand, producing high‐value chiral α‐(hetero)aryl‐substituted amines and their derivatives under mild conditions, is reported. The potential synthetic applications of this transformation are demonstrated by the concise synthesis of (S)‐nicotine and a CDK8 inhibitor.
Ligand Relay Catalysis Enables Asymmetric Migratory Hydroarylation for the Concise Synthesis of Chiral α‐(Hetero)Aryl‐Substituted Amines
Zhou, Junqian (author) / He, Yuli (author) / Liu, Zihao (author) / Wang, You (author) / Zhu, Shaolin (author)
Advanced Science ; 11
2024-04-01
6 pages
Article (Journal)
Electronic Resource
English
Synthesis and some transformations of 4-aryl-substituted amines of the tetrahydropyran series
| British Library Online Contents | 2011
Monofluorinated aziridines in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines
| British Library Online Contents | 2010
Metal-Organic Frameworks for Asymmetric Catalysis and Chiral Separations
| British Library Online Contents | 2007
Catalytic Asymmetric Construction of α,α‐Diaryl Aldehydes via Oxo‐Hydroarylation of Terminal Alkynes
| Wiley | 2024