A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Epigenotoxicity of Titanium Dioxide Nanoparticles
Titanium dioxide nanoparticles (TiO 2 NPs) are widely manufactured, with a range of applications in consumer products. Significant toxicity of TiO 2 NPs has, however, been recognized, suggesting considerable risk to human health. To fully evaluate their potential for harm, consideration of the epigenotoxicity of these nanoparticles is critical. Altered epigenetic mechanisms are known to play an essential role in the development and progression of human diseases. The chapter reviews the epigenetic activity of TiO 2 NPs. Studies have been conducted in human‐ and animal‐derived cellular systems and in animal models showing that TiO 2 NPs induce changes in DNA methylation, histone modifications, and the expression of microRNAs. Integration of epigenetics, as a necessary and beneficial component in the risk assessment of TiO 2 NPs, is discussed with the application of adverse outcome pathways (AOPs) as a potentially useful approach. Epigenetics‐based AOPs have been proposed for several metal toxicants; however, challenges remain. In the safety assessment of nanoparticles, there is also the need to understand how they are distributed in the body after exposure, and how they interact with pertinent organs and cells. Evidence establishing the cellular uptake and tissue biodistribution of TiO 2 NPs in various systems has been reported. Additionally, epidemiological studies have shown the potential harm associated with exposure to TiO 2 NPs in human populations.
Epigenotoxicity of Titanium Dioxide Nanoparticles
Titanium dioxide nanoparticles (TiO 2 NPs) are widely manufactured, with a range of applications in consumer products. Significant toxicity of TiO 2 NPs has, however, been recognized, suggesting considerable risk to human health. To fully evaluate their potential for harm, consideration of the epigenotoxicity of these nanoparticles is critical. Altered epigenetic mechanisms are known to play an essential role in the development and progression of human diseases. The chapter reviews the epigenetic activity of TiO 2 NPs. Studies have been conducted in human‐ and animal‐derived cellular systems and in animal models showing that TiO 2 NPs induce changes in DNA methylation, histone modifications, and the expression of microRNAs. Integration of epigenetics, as a necessary and beneficial component in the risk assessment of TiO 2 NPs, is discussed with the application of adverse outcome pathways (AOPs) as a potentially useful approach. Epigenetics‐based AOPs have been proposed for several metal toxicants; however, challenges remain. In the safety assessment of nanoparticles, there is also the need to understand how they are distributed in the body after exposure, and how they interact with pertinent organs and cells. Evidence establishing the cellular uptake and tissue biodistribution of TiO 2 NPs in various systems has been reported. Additionally, epidemiological studies have shown the potential harm associated with exposure to TiO 2 NPs in human populations.
Epigenotoxicity of Titanium Dioxide Nanoparticles
Sahu, Saura C. (editor) / Wells, Carlos (author) / Pogribna, Marta (author) / Lyn‐Cook, Beverly (author) / Hammons, George (author)
2023-05-15
42 pages
Article/Chapter (Book)
Electronic Resource
English
Photocatalytic Cementitious Composites containing Mesoporous Titanium Dioxide Nanoparticles
| DOAJ | 2014
Neurotoxicity Study with Titanium Dioxide Nanoparticles on Rat
| British Library Conference Proceedings | 2022
Growth of carbon nanotubes from titanium dioxide nanoparticles
| British Library Online Contents | 2012
Fabrication of titanium dioxide nanofibers containing hydroxyapatite nanoparticles
| British Library Online Contents | 2010
Photocatalytic activity of titanium dioxide modified by Fe2O3 nanoparticles
| British Library Online Contents | 2014