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Metabolic Fate Modeling of Selected Human Pharmaceuticals in Soils
As a consequence of human pharmaceuticals being found in surface, ground and drinking water, there is growing interest in their fate and behavior in soil environments. Therefore, laboratory tests on the degradation of the14C‐labeled model substances ibuprofen and diazepam were performed in two different soils. Based on the results of the laboratory‐batch experiments, metabolic fate models have been devised using model discriminating techniques based on likelihood tests for nested models. Although, the data for ibuprofen fit well into the frame of linear compartment theory, the diazepam data show pronounced nonlinearities. The kinetic behavior of both pharmaceuticals in soil is characterized by the participation of microbial processes in the formation of non‐extractable residues and by low degradation rates out of the non‐extractable fractions. An accumulation of those non‐extractable residues may occur in soils under simulated multiple contaminations.
Metabolic Fate Modeling of Selected Human Pharmaceuticals in Soils
As a consequence of human pharmaceuticals being found in surface, ground and drinking water, there is growing interest in their fate and behavior in soil environments. Therefore, laboratory tests on the degradation of the14C‐labeled model substances ibuprofen and diazepam were performed in two different soils. Based on the results of the laboratory‐batch experiments, metabolic fate models have been devised using model discriminating techniques based on likelihood tests for nested models. Although, the data for ibuprofen fit well into the frame of linear compartment theory, the diazepam data show pronounced nonlinearities. The kinetic behavior of both pharmaceuticals in soil is characterized by the participation of microbial processes in the formation of non‐extractable residues and by low degradation rates out of the non‐extractable fractions. An accumulation of those non‐extractable residues may occur in soils under simulated multiple contaminations.
Metabolic Fate Modeling of Selected Human Pharmaceuticals in Soils
Richter, Otto (author) / Kullmer, Christoph (author) / Kreuzig, Robert (author)
CLEAN – Soil, Air, Water ; 35 ; 495-503
2007-11-01
9 pages
Article (Journal)
Electronic Resource
English
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