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Reproductive and developmental toxicity screening study of 2,4‐dinitrophenol in rats
10.1002/tox.20398.abs
Rats were treated by gavage once daily with 2,4‐dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40–47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and females of any group. A significant decrease in body weight gain and significant increase in liver weight were found in males and females at 30 mg/kg bw/day. The number of live pups on postnatal days (PNDs) 0 and 4, live birth index, and body weight of live male and female pups on PNDs 0 and 1 were significantly lowered at 30 mg/kg bw/day. External and internal examinations of pups revealed no increased incidence of malformations in DNP‐treated groups. On the basis of these findings, we concluded that DNP has general and reproductive/developmental toxicity, but not teratogenicity, under the present conditions. The NOAEL of DNP is considered to be 10 mg/kg bw/day in rats. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
Reproductive and developmental toxicity screening study of 2,4‐dinitrophenol in rats
10.1002/tox.20398.abs
Rats were treated by gavage once daily with 2,4‐dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40–47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and females of any group. A significant decrease in body weight gain and significant increase in liver weight were found in males and females at 30 mg/kg bw/day. The number of live pups on postnatal days (PNDs) 0 and 4, live birth index, and body weight of live male and female pups on PNDs 0 and 1 were significantly lowered at 30 mg/kg bw/day. External and internal examinations of pups revealed no increased incidence of malformations in DNP‐treated groups. On the basis of these findings, we concluded that DNP has general and reproductive/developmental toxicity, but not teratogenicity, under the present conditions. The NOAEL of DNP is considered to be 10 mg/kg bw/day in rats. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
Reproductive and developmental toxicity screening study of 2,4‐dinitrophenol in rats
Takahashi, Mika (author) / Sunaga, Masao (author) / Hirata‐Koizumi, Mutsuko (author) / Hirose, Akihiko (author) / Kamata, Eiichi (author) / Ema, Makoto (author)
Environmental Toxicology ; 24 ; 74-81
2009-02-01
8 pages
Article (Journal)
Electronic Resource
English
Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats
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