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Reaction Optimization of a Suzuki‐Miyaura Cross‐Coupling Using Design of Experiments
The combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error‐prone manual work. A self‐developed software tool allows for creating fractional‐factorial experimental design (FFED). Application of FFED on the screening of a Suzuki‐Miyaura cross‐coupling leads to a 93 % reduced design compared to full‐factorial design. The resulting regression model qualitatively shows the positive effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations.
Reaction Optimization of a Suzuki‐Miyaura Cross‐Coupling Using Design of Experiments
The combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error‐prone manual work. A self‐developed software tool allows for creating fractional‐factorial experimental design (FFED). Application of FFED on the screening of a Suzuki‐Miyaura cross‐coupling leads to a 93 % reduced design compared to full‐factorial design. The resulting regression model qualitatively shows the positive effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations.
Reaction Optimization of a Suzuki‐Miyaura Cross‐Coupling Using Design of Experiments
Bobers, Jens (author) / Hahn, Lisa Katharina (author) / Averbeck, Tobias (author) / Brunschweiger, Andreas (author) / Kockmann, Norbert (author)
Chemie Ingenieur Technik ; 94 ; 780-785
2022-05-01
6 pages
Article (Journal)
Electronic Resource
English
| British Library Online Contents | 2016