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Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy
The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions and immune checkpoint inhibitors efficiently and simultaneously to tumors. Herein, a mitochondria‐targeted nanoscale coordination polymer particle, Cu/TI, comprising Cu(II), and a triphenylphosphonium conjugate of 5‐carboxy‐8‐hydroxyquinoline (TI), for effective cuproptosis induction and programmed cell death‐1 (PD‐L1) downregulation is reported. Upon systemic administration, Cu/TI efficiently accumulates in tumor tissues to induce immunogenic cancer cell death and reduce PD‐L1 expression. Consequently, Cu/TI promotes the intratumoral infiltration and activation of cytotoxic T lymphocytes to greatly inhibit tumor progression of colorectal carcinoma and triple‐negative breast cancer in mouse models without causing obvious side effects.
Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy
The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions and immune checkpoint inhibitors efficiently and simultaneously to tumors. Herein, a mitochondria‐targeted nanoscale coordination polymer particle, Cu/TI, comprising Cu(II), and a triphenylphosphonium conjugate of 5‐carboxy‐8‐hydroxyquinoline (TI), for effective cuproptosis induction and programmed cell death‐1 (PD‐L1) downregulation is reported. Upon systemic administration, Cu/TI efficiently accumulates in tumor tissues to induce immunogenic cancer cell death and reduce PD‐L1 expression. Consequently, Cu/TI promotes the intratumoral infiltration and activation of cytotoxic T lymphocytes to greatly inhibit tumor progression of colorectal carcinoma and triple‐negative breast cancer in mouse models without causing obvious side effects.
Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy
Li, Youyou (author) / Liu, Jing (author) / Weichselbaum, Ralph R. (author) / Lin, Wenbin (author)
Advanced Science ; 11
2024-09-01
11 pages
Article (Journal)
Electronic Resource
English
Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
| Wiley | 2024
Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
| Wiley | 2024
| Wiley | 2024
| Wiley | 2024