Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Magnetic keratin/hydrotalcites sponges as potential scaffolds for tissue regeneration
Abstract In this work, keratin sponges (Ks) containing magnetic MgFe hydrotalcites (HTlc) nanoparticles were prepared by freeze-drying and tested as 3D scaffolds for tissue regeneration. HTlc nanoparticles were well dispersed in the protein matrix and preserved their lamellar structure. The obtained hybrid materials showed a mean pore diameter of about 48 μm and a swelling ratio of about 6, higher than that of pure Ks (~ 4). Magnetic measurements indicated that the Ks-HTlc samples were magnetized more easily that the pure HTlc ones. Finally, the cell viability test, performed on osteoblasts under the effect of an applied static magnetic field, showed a substantial increase in cellular activity in the hybrid Ks-HTlc sponges compared to the nonmagnetic Ks sponges. Taken together, the reported results indicate that combining keratin with magnetic HTlc nanoparticles is a good strategy to obtain innovative 3D scaffold of potential interest in tissue regeneration, especially bone.
Graphical abstract Display Omitted
Highlights Keratin sponges containing MgFe hydrotalcites were prepared by freeze-drying. Magnetic hydrotalcites were homogenously incorporated into keratin matrix. Hybrid keratin-HTlc samples were magnetized more easily that pure HTlc ones. Increased cellular activity was observed for hybrid sponges under magnetic field.
Magnetic keratin/hydrotalcites sponges as potential scaffolds for tissue regeneration
Abstract In this work, keratin sponges (Ks) containing magnetic MgFe hydrotalcites (HTlc) nanoparticles were prepared by freeze-drying and tested as 3D scaffolds for tissue regeneration. HTlc nanoparticles were well dispersed in the protein matrix and preserved their lamellar structure. The obtained hybrid materials showed a mean pore diameter of about 48 μm and a swelling ratio of about 6, higher than that of pure Ks (~ 4). Magnetic measurements indicated that the Ks-HTlc samples were magnetized more easily that the pure HTlc ones. Finally, the cell viability test, performed on osteoblasts under the effect of an applied static magnetic field, showed a substantial increase in cellular activity in the hybrid Ks-HTlc sponges compared to the nonmagnetic Ks sponges. Taken together, the reported results indicate that combining keratin with magnetic HTlc nanoparticles is a good strategy to obtain innovative 3D scaffold of potential interest in tissue regeneration, especially bone.
Graphical abstract Display Omitted
Highlights Keratin sponges containing MgFe hydrotalcites were prepared by freeze-drying. Magnetic hydrotalcites were homogenously incorporated into keratin matrix. Hybrid keratin-HTlc samples were magnetized more easily that pure HTlc ones. Increased cellular activity was observed for hybrid sponges under magnetic field.
Magnetic keratin/hydrotalcites sponges as potential scaffolds for tissue regeneration
Giannelli, Marta (Autor:in) / Barbalinardo, Marianna (Autor:in) / Riminucci, Alberto (Autor:in) / Belvedere, Katia (Autor:in) / Boccalon, Elisa (Autor:in) / Sotgiu, Giovanna (Autor:in) / Corticelli, Franco (Autor:in) / Ruani, Giampiero (Autor:in) / Zamboni, Roberto (Autor:in) / Aluigi, Annalisa (Autor:in)
Applied Clay Science ; 207
01.04.2021
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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