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Magnetic keratin/hydrotalcites sponges as potential scaffolds for tissue regeneration
Abstract In this work, keratin sponges (Ks) containing magnetic MgFe hydrotalcites (HTlc) nanoparticles were prepared by freeze-drying and tested as 3D scaffolds for tissue regeneration. HTlc nanoparticles were well dispersed in the protein matrix and preserved their lamellar structure. The obtained hybrid materials showed a mean pore diameter of about 48 μm and a swelling ratio of about 6, higher than that of pure Ks (~ 4). Magnetic measurements indicated that the Ks-HTlc samples were magnetized more easily that the pure HTlc ones. Finally, the cell viability test, performed on osteoblasts under the effect of an applied static magnetic field, showed a substantial increase in cellular activity in the hybrid Ks-HTlc sponges compared to the nonmagnetic Ks sponges. Taken together, the reported results indicate that combining keratin with magnetic HTlc nanoparticles is a good strategy to obtain innovative 3D scaffold of potential interest in tissue regeneration, especially bone.
Graphical abstract Display Omitted
Highlights Keratin sponges containing MgFe hydrotalcites were prepared by freeze-drying. Magnetic hydrotalcites were homogenously incorporated into keratin matrix. Hybrid keratin-HTlc samples were magnetized more easily that pure HTlc ones. Increased cellular activity was observed for hybrid sponges under magnetic field.
Magnetic keratin/hydrotalcites sponges as potential scaffolds for tissue regeneration
Abstract In this work, keratin sponges (Ks) containing magnetic MgFe hydrotalcites (HTlc) nanoparticles were prepared by freeze-drying and tested as 3D scaffolds for tissue regeneration. HTlc nanoparticles were well dispersed in the protein matrix and preserved their lamellar structure. The obtained hybrid materials showed a mean pore diameter of about 48 μm and a swelling ratio of about 6, higher than that of pure Ks (~ 4). Magnetic measurements indicated that the Ks-HTlc samples were magnetized more easily that the pure HTlc ones. Finally, the cell viability test, performed on osteoblasts under the effect of an applied static magnetic field, showed a substantial increase in cellular activity in the hybrid Ks-HTlc sponges compared to the nonmagnetic Ks sponges. Taken together, the reported results indicate that combining keratin with magnetic HTlc nanoparticles is a good strategy to obtain innovative 3D scaffold of potential interest in tissue regeneration, especially bone.
Graphical abstract Display Omitted
Highlights Keratin sponges containing MgFe hydrotalcites were prepared by freeze-drying. Magnetic hydrotalcites were homogenously incorporated into keratin matrix. Hybrid keratin-HTlc samples were magnetized more easily that pure HTlc ones. Increased cellular activity was observed for hybrid sponges under magnetic field.
Magnetic keratin/hydrotalcites sponges as potential scaffolds for tissue regeneration
Giannelli, Marta (author) / Barbalinardo, Marianna (author) / Riminucci, Alberto (author) / Belvedere, Katia (author) / Boccalon, Elisa (author) / Sotgiu, Giovanna (author) / Corticelli, Franco (author) / Ruani, Giampiero (author) / Zamboni, Roberto (author) / Aluigi, Annalisa (author)
Applied Clay Science ; 207
2021-04-01
Article (Journal)
Electronic Resource
English
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