Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
In utero exposure to organochlorine pesticides and early menarche in the Avon Longitudinal Study of Parents and Children
Abstract Introduction Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited. Methods Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5years of age (cases) and 230 girls who reported menarche at or after 11.5years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI. Results We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche. Conclusions This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.
Highlights Organochlorine pesticides (OCPs) are still detected in populations despite bans. The association between in utero exposure to OCPs and early menarche is examined. No association was found between in utero exposure to OCPs and early menarche.
In utero exposure to organochlorine pesticides and early menarche in the Avon Longitudinal Study of Parents and Children
Abstract Introduction Epidemiologic data supporting the role of organochlorine pesticides in pubertal development are limited. Methods Using a nested case-control design, serum collected during pregnancy from mothers of 218 girls who reported menarche before 11.5years of age (cases) and 230 girls who reported menarche at or after 11.5years of age (controls) was analyzed for 9 organochlorines and metabolites. We analyzed the association between in utero organochlorine concentrations and early menarche using multivariate logistic regression controlling for mother's age at menarche, or mother's prenatal BMI. Results We did not observe an association between in utero exposure to HCB, β-HCH, ϒ-HCH, p,p′-DDT, p,p′-DDE, oxychlordane or trans-nonachlor and early menarche. Conclusions This study is the first to examine the association between in utero exposure to HCB, β-HCH, ϒ-HCH, oxychlordane or trans-nonachlor and early menarche. In utero exposure to organochlorine pesticides does not appear to have a role in the timing of menarche in this study.
Highlights Organochlorine pesticides (OCPs) are still detected in populations despite bans. The association between in utero exposure to OCPs and early menarche is examined. No association was found between in utero exposure to OCPs and early menarche.
In utero exposure to organochlorine pesticides and early menarche in the Avon Longitudinal Study of Parents and Children
Namulanda, Gonza (Autor:in) / Maisonet, Mildred (Autor:in) / Taylor, Ethel (Autor:in) / Flanders, W. Dana (Autor:in) / Olson, David (Autor:in) / Sjodin, Andreas (Autor:in) / Qualters, Judith R. (Autor:in) / Vena, John (Autor:in) / Northstone, Kate (Autor:in) / Naeher, Luke (Autor:in)
Environmental International ; 94 ; 467-472
02.06.2016
6 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Prenatal exposure to organochlorine pesticides and infant growth: A longitudinal study
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