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Cytotoxicity of natural allophane nanoparticles on human lung cancer A549 cells
AbstractClay minerals are mainly used around traditional cosmetics and industrial products, but currently their target application is continuously expanding into pharmaceutical industry and tissue engineering. To broaden the knowledge of in vitro cytotoxicity of allophane nanoparticles against human cancer cells, the cytotoxicity of both natural and synthetic allophane nanoparticles for cultured human alveolar basal epithelial (A549) cells was examined. For both natural and synthetic allophones, the A549 cell viability was maintained at >70% for concentration up to 3160μg/mL, implying higher biocompatibility of allophane nanoparticles as compared with that of hectorite nanoparticles. The cell adhesion kinetics coupled with cytotoxic characteristics against A549 cells was analyzed using quartz crystal microbalance (QCM) technique to distinguish the dynamic cell adhesion signatures.
Graphical abstract
HighlightsThe cytotoxicity of allophane nanoparticles was examined.Higher biocompatibility of allophane for A549 cells was demonstrated.The estimated IC50 value of hectorite for A549 was 105μg/mL.
Cytotoxicity of natural allophane nanoparticles on human lung cancer A549 cells
AbstractClay minerals are mainly used around traditional cosmetics and industrial products, but currently their target application is continuously expanding into pharmaceutical industry and tissue engineering. To broaden the knowledge of in vitro cytotoxicity of allophane nanoparticles against human cancer cells, the cytotoxicity of both natural and synthetic allophane nanoparticles for cultured human alveolar basal epithelial (A549) cells was examined. For both natural and synthetic allophones, the A549 cell viability was maintained at >70% for concentration up to 3160μg/mL, implying higher biocompatibility of allophane nanoparticles as compared with that of hectorite nanoparticles. The cell adhesion kinetics coupled with cytotoxic characteristics against A549 cells was analyzed using quartz crystal microbalance (QCM) technique to distinguish the dynamic cell adhesion signatures.
Graphical abstract
HighlightsThe cytotoxicity of allophane nanoparticles was examined.Higher biocompatibility of allophane for A549 cells was demonstrated.The estimated IC50 value of hectorite for A549 was 105μg/mL.
Cytotoxicity of natural allophane nanoparticles on human lung cancer A549 cells
Toyota, Yusuke (Autor:in) / Matsuura, Yoko (Autor:in) / Ito, Masashi (Autor:in) / Domura, Ryota (Autor:in) / Okamoto, Masami (Autor:in) / Arakawa, Shuichi (Autor:in) / Hirano, Minoru (Autor:in) / Kohda, Katsunori (Autor:in)
Applied Clay Science ; 135 ; 485-492
21.10.2016
8 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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