Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Amorphous calcium phosphate with excellent compression resistance and preparation method and application thereof
The invention discloses modified amorphous calcium phosphate with excellent compression resistance. The modified amorphous calcium phosphate comprises the following components in parts by weight: 0.1-0.5 part of rare earth, 0.1-0.5 part of a magnesium salt, 1-5 parts of a sodium hydroxide solution, 100-300 parts of a calcium salt and 100-300 parts of phosphate. A preparation method of the modifiedamorphous calcium phosphate with excellent compression resistance comprises the following steps: S1, respectively adding rare earth substances and soluble magnesium salt into pure water, and dropwiseadding a sodium hydroxide solution, S2, carrying out stirring for a hydrothermal reaction, and S3, discharging, filtering, washing, drying to constant weight, and grinding to obtain the nano powder.The modified amorphous calcium phosphate is used for the biomedical 3D printing material. According to the invention, the mineralization phase change capability is recovered and the internal binding force of hydration product crystals is remarkably enhanced, so that a printed bone finished product with very excellent mechanical strength, especially compressive strength, is prepared, and the technical bottleneck that the printed bone finished product cannot be used for treating and repairing bearing bones of organisms is thoroughly overcome. In addition, the preparation method has the characteristics of high stability and high purity.
本发明所述的抗压性能优异的改性无定形磷酸钙，包括0.1～0.5份稀土、0.1～0.5份镁盐、1～5份氢氧化钠溶液、100～300份钙盐、以及100～300份磷酸盐。本发明所述的抗压性能优异的改性无定形磷酸钙的制备方法，包括S1.将稀土物质和可溶性镁盐分别加到纯水中，滴入氢氧化钠溶液；S2.搅拌，进行水热反应；S3.出料，过滤、洗涤、干燥至恒重，研磨制得纳米粉体。本发明用于生物医学3D打印材料。本发明不仅重新恢复了矿化相变的能力，而且水化产物晶体的内在结合力显著增强，从而制成机械强度，尤其是抗压强度非常优异的打印骨成品，彻底攻克了打印骨成品无法用于生物体承重骨治疗修复的技术瓶颈。此外，本发明具有高稳定性、高纯净度的特点。
Amorphous calcium phosphate with excellent compression resistance and preparation method and application thereof
The invention discloses modified amorphous calcium phosphate with excellent compression resistance. The modified amorphous calcium phosphate comprises the following components in parts by weight: 0.1-0.5 part of rare earth, 0.1-0.5 part of a magnesium salt, 1-5 parts of a sodium hydroxide solution, 100-300 parts of a calcium salt and 100-300 parts of phosphate. A preparation method of the modifiedamorphous calcium phosphate with excellent compression resistance comprises the following steps: S1, respectively adding rare earth substances and soluble magnesium salt into pure water, and dropwiseadding a sodium hydroxide solution, S2, carrying out stirring for a hydrothermal reaction, and S3, discharging, filtering, washing, drying to constant weight, and grinding to obtain the nano powder.The modified amorphous calcium phosphate is used for the biomedical 3D printing material. According to the invention, the mineralization phase change capability is recovered and the internal binding force of hydration product crystals is remarkably enhanced, so that a printed bone finished product with very excellent mechanical strength, especially compressive strength, is prepared, and the technical bottleneck that the printed bone finished product cannot be used for treating and repairing bearing bones of organisms is thoroughly overcome. In addition, the preparation method has the characteristics of high stability and high purity.
本发明所述的抗压性能优异的改性无定形磷酸钙，包括0.1～0.5份稀土、0.1～0.5份镁盐、1～5份氢氧化钠溶液、100～300份钙盐、以及100～300份磷酸盐。本发明所述的抗压性能优异的改性无定形磷酸钙的制备方法，包括S1.将稀土物质和可溶性镁盐分别加到纯水中，滴入氢氧化钠溶液；S2.搅拌，进行水热反应；S3.出料，过滤、洗涤、干燥至恒重，研磨制得纳米粉体。本发明用于生物医学3D打印材料。本发明不仅重新恢复了矿化相变的能力，而且水化产物晶体的内在结合力显著增强，从而制成机械强度，尤其是抗压强度非常优异的打印骨成品，彻底攻克了打印骨成品无法用于生物体承重骨治疗修复的技术瓶颈。此外，本发明具有高稳定性、高纯净度的特点。
Amorphous calcium phosphate with excellent compression resistance and preparation method and application thereof
一种抗压性能优异的无定形磷酸钙及其制备方法和应用
NIE JIANHUA (Autor:in)
17.07.2020
Patent
Elektronische Ressource
Chinesisch
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