Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Medical bone regeneration and repair nano biological ceramic material, preparation method and application thereof
The invention discloses a medical bone regeneration and repair nano biological ceramic material, a preparation method and application thereof. The material is prepared from Ag-doped nano zinc oxide powder and biphasic calcium phosphate ceramic, wherein in the Ag-doped nano zinc oxide powder, a molar ratio of Zn<2+> to Ag<+> is 2-4:1, the biphasic calcium phosphate ceramic is composed of hydroxyapatite and beta-tricalcium phosphate, and a mass ratio of hydroxyapatite to beta-tricalcium phosphate is 1:1-3. According to the invention, porous calcium phosphate nano ceramic microspheres with function of synergistically and controllably releasing Ag and ZnO are constructed, and have excellent bone defect repairing capability, so that the purposes of inducing regeneration and repairing of infectious bone defect tissues and resisting bacteria for a long time are achieved, and the possibility is provided for realizing efficient loading of antibacterial drugs.
本发明公开了一种医用骨再生修复纳米生物陶瓷材料及其制备方法与应用，所述材料由掺杂Ag的纳米氧化锌粉体和双相磷酸钙陶瓷制成，其中：掺杂Ag的纳米氧化锌粉体中，Zn2+和Ag+的摩尔比为2~4:1；双相磷酸钙陶瓷为由羟基磷灰石和β‑磷酸三钙两相成分构成的陶瓷，羟基磷灰石和β‑磷酸三钙的质量比为1:1~3。本发明构建了具有协同可控释放Ag和ZnO功能的多孔磷酸钙纳米陶瓷微球，多孔球形磷酸钙纳米陶瓷颗粒具有优异的骨缺损修复能力，进而达到诱导感染性骨缺损组织再生修复和长效抗菌的目的，为实现抗菌药物的高效装载提供了可能。
Medical bone regeneration and repair nano biological ceramic material, preparation method and application thereof
The invention discloses a medical bone regeneration and repair nano biological ceramic material, a preparation method and application thereof. The material is prepared from Ag-doped nano zinc oxide powder and biphasic calcium phosphate ceramic, wherein in the Ag-doped nano zinc oxide powder, a molar ratio of Zn<2+> to Ag<+> is 2-4:1, the biphasic calcium phosphate ceramic is composed of hydroxyapatite and beta-tricalcium phosphate, and a mass ratio of hydroxyapatite to beta-tricalcium phosphate is 1:1-3. According to the invention, porous calcium phosphate nano ceramic microspheres with function of synergistically and controllably releasing Ag and ZnO are constructed, and have excellent bone defect repairing capability, so that the purposes of inducing regeneration and repairing of infectious bone defect tissues and resisting bacteria for a long time are achieved, and the possibility is provided for realizing efficient loading of antibacterial drugs.
本发明公开了一种医用骨再生修复纳米生物陶瓷材料及其制备方法与应用，所述材料由掺杂Ag的纳米氧化锌粉体和双相磷酸钙陶瓷制成，其中：掺杂Ag的纳米氧化锌粉体中，Zn2+和Ag+的摩尔比为2~4:1；双相磷酸钙陶瓷为由羟基磷灰石和β‑磷酸三钙两相成分构成的陶瓷，羟基磷灰石和β‑磷酸三钙的质量比为1:1~3。本发明构建了具有协同可控释放Ag和ZnO功能的多孔磷酸钙纳米陶瓷微球，多孔球形磷酸钙纳米陶瓷颗粒具有优异的骨缺损修复能力，进而达到诱导感染性骨缺损组织再生修复和长效抗菌的目的，为实现抗菌药物的高效装载提供了可能。
Medical bone regeneration and repair nano biological ceramic material, preparation method and application thereof
一种医用骨再生修复纳米生物陶瓷材料及其制备方法与应用
LYU YUGUANG (Autor:in) / ZHANG LINLIN (Autor:in) / WU JIANG (Autor:in) / ZHANG GUOLIANG (Autor:in) / REN HENGXIN (Autor:in) / LI QIAO (Autor:in) / CHENG YUQING (Autor:in)
12.02.2021
Patent
Elektronische Ressource
Chinesisch
IPC:
C04B
Kalk
,
LIME
/
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B22F
Verarbeiten von Metallpulver
,
WORKING METALLIC POWDER
/
B82Y
Bestimmter Gebrauch oder bestimmte Anwendung von Nanostrukturen
,
SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
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