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Ultrasonic response immunoregulation piezoelectric ceramic bone scaffold and preparation method thereof
The invention discloses an ultrasonic response immunoregulation piezoelectric ceramic bone scaffold and a preparation method thereof, and belongs to the technical field of bone tissue repair biomedical engineering, and liquid-phase light-cured resin, solid-phase nano-scale hydroxyapatite powder and solid-phase micron-scale barium titanate powder are mixed to obtain 3D printing slurry. And printing the slurry into a bracket blank by using a digital light processing technology, and drying, degreasing, sintering, silver firing and polarizing to obtain the bracket. The immunoregulation piezoelectric ceramic bone scaffold is high in precision, controllable in porosity, appropriate in pore size and good in mechanical property; in addition, in the aspects of filling bone defects and promoting cell proliferation and osteogenic differentiation, the piezoelectric property introduced by the stent material is improved by the composite micron-sized barium titanate, the stent surface is induced to generate micro current under the stimulation of low-intensity pulsed ultrasound, and the electrical property of natural bone tissues is simulated. The scaffold material can promote M2-direction polarization of macrophages on the surface of the scaffold material under low-intensity pulse ultrasonic stimulation, so that inflammation is inhibited, and tissue regeneration is promoted.
本发明公开了一种超声响应的免疫调节压电陶瓷骨支架及制备方法，属于骨组织修复生物医学工程技术领域，是将液相光固化树脂和固相纳米级羟基磷灰石粉体及固相微米级钛酸钡粉体混合后得到3D打印浆料。利用数字光处理技术将浆料打印成支架坯体，经过干燥、脱脂、烧结、烧银、极化后得到。该免疫调节压电陶瓷骨支架精度高、孔隙率可控、孔径大小合适，具有良好的力学性能；且在填补骨缺损，促进细胞增殖和成骨向分化，复合的微米级钛酸钡更为支架材料引入的压电性能，在低强度脉冲超声刺激下诱导支架表明产生微电流，模拟自然骨组织的电学性能。该支架材料还能低强度脉冲超声刺激下促进其表面巨噬细胞M2向极化，进而抑制炎症产生，从而促进组织再生。
Ultrasonic response immunoregulation piezoelectric ceramic bone scaffold and preparation method thereof
The invention discloses an ultrasonic response immunoregulation piezoelectric ceramic bone scaffold and a preparation method thereof, and belongs to the technical field of bone tissue repair biomedical engineering, and liquid-phase light-cured resin, solid-phase nano-scale hydroxyapatite powder and solid-phase micron-scale barium titanate powder are mixed to obtain 3D printing slurry. And printing the slurry into a bracket blank by using a digital light processing technology, and drying, degreasing, sintering, silver firing and polarizing to obtain the bracket. The immunoregulation piezoelectric ceramic bone scaffold is high in precision, controllable in porosity, appropriate in pore size and good in mechanical property; in addition, in the aspects of filling bone defects and promoting cell proliferation and osteogenic differentiation, the piezoelectric property introduced by the stent material is improved by the composite micron-sized barium titanate, the stent surface is induced to generate micro current under the stimulation of low-intensity pulsed ultrasound, and the electrical property of natural bone tissues is simulated. The scaffold material can promote M2-direction polarization of macrophages on the surface of the scaffold material under low-intensity pulse ultrasonic stimulation, so that inflammation is inhibited, and tissue regeneration is promoted.
本发明公开了一种超声响应的免疫调节压电陶瓷骨支架及制备方法，属于骨组织修复生物医学工程技术领域，是将液相光固化树脂和固相纳米级羟基磷灰石粉体及固相微米级钛酸钡粉体混合后得到3D打印浆料。利用数字光处理技术将浆料打印成支架坯体，经过干燥、脱脂、烧结、烧银、极化后得到。该免疫调节压电陶瓷骨支架精度高、孔隙率可控、孔径大小合适，具有良好的力学性能；且在填补骨缺损，促进细胞增殖和成骨向分化，复合的微米级钛酸钡更为支架材料引入的压电性能，在低强度脉冲超声刺激下诱导支架表明产生微电流，模拟自然骨组织的电学性能。该支架材料还能低强度脉冲超声刺激下促进其表面巨噬细胞M2向极化，进而抑制炎症产生，从而促进组织再生。
Ultrasonic response immunoregulation piezoelectric ceramic bone scaffold and preparation method thereof
一种超声响应的免疫调节压电陶瓷骨支架及制备方法
WU GUOMIN (Autor:in) / CHEN KAI (Autor:in) / WANG YINGTONG (Autor:in) / ZHENG SHIKANG (Autor:in) / TANG HAOYU (Autor:in) / ZHOU ZHENGJIE (Autor:in) / ZHENG HAOYU (Autor:in) / WANG LIN (Autor:in) / ZHANG MINGJUN (Autor:in) / ZHU ZIHE (Autor:in)
08.03.2024
Patent
Elektronische Ressource
Chinesisch
IPC:
C04B
Kalk
,
LIME
/
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
/
H10N
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