Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Functionalized hydroxyapatite nano ceramic as well as preparation method and application thereof
The invention relates to functionalized hydroxyapatite nano ceramic as well as a preparation method and application thereof, and belongs to the field of biomedical engineering and material science. According to the preparation method, high-purity and high-porosity hydroxyapatite porous ceramic is adopted as a substrate material, firstly, the surface roughness of the hydroxyapatite porous ceramic is increased through pretreatment of a nitric acid solution, and an amorphous calcium phosphate layer is formed on the surface of the hydroxyapatite porous ceramic; then, a hydrothermal method is adopted for treatment, and therefore the functionalized hydroxyapatite nano ceramic with improved biological activity and bone regeneration promoting capacity is prepared. The biocompatibility and the chemical stability of the functionalized hydroxyapatite nano ceramic are remarkably improved, and the functionalized hydroxyapatite nano ceramic shows excellent biological activity. Therefore, the functionalized hydroxyapatite nano ceramic can be used as an ideal bone defect filling material, is widely applied to bone tissue engineering and bone defect repair projects, and provides assistance for the research and practice of promoting bone tissue regeneration and bone defect treatment.
本发明涉及一种功能化羟基磷灰石纳米陶瓷及其制备方法和应用，属于生物医学工程和材料科学领域。本发明采用高纯度、高孔隙率的羟基磷灰石多孔陶瓷作为基底材料，首先通过硝酸溶液预处理，增加所述羟基磷灰石多孔陶瓷的表面粗糙度并在其表面形成无定形磷酸钙层。接着，采用水热法进行处理，从而制备出具有改进的生物活性和促进骨再生能力的功能化羟基磷灰石纳米陶瓷。所述功能化羟基磷灰石纳米陶瓷的生物相容性和化学稳定性显著提升，并展现出优异的生物活性。因此，所述功能化羟基磷灰石纳米陶瓷可作为一种理想的骨缺损填充材料，广泛应用于骨组织工程和骨缺损修复项目，且为推进骨组织再生和骨缺损治疗的研究与实践提供了助力。
Functionalized hydroxyapatite nano ceramic as well as preparation method and application thereof
The invention relates to functionalized hydroxyapatite nano ceramic as well as a preparation method and application thereof, and belongs to the field of biomedical engineering and material science. According to the preparation method, high-purity and high-porosity hydroxyapatite porous ceramic is adopted as a substrate material, firstly, the surface roughness of the hydroxyapatite porous ceramic is increased through pretreatment of a nitric acid solution, and an amorphous calcium phosphate layer is formed on the surface of the hydroxyapatite porous ceramic; then, a hydrothermal method is adopted for treatment, and therefore the functionalized hydroxyapatite nano ceramic with improved biological activity and bone regeneration promoting capacity is prepared. The biocompatibility and the chemical stability of the functionalized hydroxyapatite nano ceramic are remarkably improved, and the functionalized hydroxyapatite nano ceramic shows excellent biological activity. Therefore, the functionalized hydroxyapatite nano ceramic can be used as an ideal bone defect filling material, is widely applied to bone tissue engineering and bone defect repair projects, and provides assistance for the research and practice of promoting bone tissue regeneration and bone defect treatment.
本发明涉及一种功能化羟基磷灰石纳米陶瓷及其制备方法和应用，属于生物医学工程和材料科学领域。本发明采用高纯度、高孔隙率的羟基磷灰石多孔陶瓷作为基底材料，首先通过硝酸溶液预处理，增加所述羟基磷灰石多孔陶瓷的表面粗糙度并在其表面形成无定形磷酸钙层。接着，采用水热法进行处理，从而制备出具有改进的生物活性和促进骨再生能力的功能化羟基磷灰石纳米陶瓷。所述功能化羟基磷灰石纳米陶瓷的生物相容性和化学稳定性显著提升，并展现出优异的生物活性。因此，所述功能化羟基磷灰石纳米陶瓷可作为一种理想的骨缺损填充材料，广泛应用于骨组织工程和骨缺损修复项目，且为推进骨组织再生和骨缺损治疗的研究与实践提供了助力。
Functionalized hydroxyapatite nano ceramic as well as preparation method and application thereof
功能化羟基磷灰石纳米陶瓷及其制备方法和应用
ZHAO RUI (Autor:in) / ZHUANG LEI (Autor:in)
10.09.2024
Patent
Elektronische Ressource
Chinesisch
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