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Quinazoline analogs as receptor tyrosine kinase inhibitors
This invention provides quinazoline analogs of Formula (I): where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R 3 groups. The invention also includes methods of using compounds of Formula (I) as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Quinazoline analogs as receptor tyrosine kinase inhibitors
This invention provides quinazoline analogs of Formula (I): where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R 3 groups. The invention also includes methods of using compounds of Formula (I) as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Quinazoline analogs as receptor tyrosine kinase inhibitors
WALLACE ELI (Autor:in) / LYSSIKATOS JOSEPH (Autor:in) / TOPALOV GEORGE (Autor:in) / BUCKMELTER ALEXANDRE (Autor:in) / ZHAO QIAN (Autor:in)
05.03.2019
Patent
Elektronische Ressource
Englisch
IPC:
C07D
HETEROCYCLIC COMPOUNDS
,
Heterocyclische Verbindungen
/
A61K
Zubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke
,
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
/
A61P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
,
Spezifische therapeutische Aktivität von chemischen Verbindungen oder medizinischen Zubereitungen
/
C04B
Kalk
,
LIME
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