Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Inorganic arsenic induces necrosis of human CD34‐positive haematopoietic stem cells
10.1002/tox.20334.abs
Inorganic arsenic is a major environmental contaminant known to exert immunosuppressive effects. In this study, we report toxicity of As2O3, a trivalent inorganic form, toward isolated human hematopoietic CD34+ progenitor cells. Our results demonstrate that low concentrations of As2O3 (0.1–5 μM) inhibit in vitro proliferation of CD34+ cells and their differentiation into various hematological cell lineages. These effects were associated with the induction of a necrotic process independent of caspases and likely related to mitochondrial damage. We conclude that As2O3 can impair in vitro human hematopoiesis by decreasing survival of CD34+ progenitor cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2008.
Inorganic arsenic induces necrosis of human CD34‐positive haematopoietic stem cells
10.1002/tox.20334.abs
Inorganic arsenic is a major environmental contaminant known to exert immunosuppressive effects. In this study, we report toxicity of As2O3, a trivalent inorganic form, toward isolated human hematopoietic CD34+ progenitor cells. Our results demonstrate that low concentrations of As2O3 (0.1–5 μM) inhibit in vitro proliferation of CD34+ cells and their differentiation into various hematological cell lineages. These effects were associated with the induction of a necrotic process independent of caspases and likely related to mitochondrial damage. We conclude that As2O3 can impair in vitro human hematopoiesis by decreasing survival of CD34+ progenitor cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2008.
Inorganic arsenic induces necrosis of human CD34‐positive haematopoietic stem cells
Vernhet, Laurent (Autor:in) / Morzadec, Claudie (Autor:in) / van Grevenynghe, Julien (Autor:in) / Bareau, Benoît (Autor:in) / Corolleur, Michel (Autor:in) / Fest, Thierry (Autor:in) / Fardel, Olivier (Autor:in)
Environmental Toxicology ; 23 ; 263-268
01.04.2008
6 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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