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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

Kuepfer, L / Niederalt, C / Wendl, T / Schlender, J‐F / Willmann, S / Lippert, J / Block, M / Eissing, T / Teutonico, D

The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.

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Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

Kuepfer, L / Niederalt, C / Wendl, T / Schlender, J‐F / Willmann, S / Lippert, J / Block, M / Eissing, T / Teutonico, D

The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

Kuepfer, L / Niederalt, C / Wendl, T / Schlender, J‐F / Willmann, S / Lippert, J / Block, M / Eissing, T / Teutonico, D

The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.

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Titel:

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

Beteiligte:

Kuepfer, L (Autor:in) / Niederalt, C (Autor:in) / Wendl, T (Autor:in) / Schlender, J‐F (Autor:in) / Willmann, S (Autor:in) / Lippert, J (Autor:in) / Block, M (Autor:in) / Eissing, T (Autor:in) / Teutonico, D (Autor:in)

Erschienen in:

CPT: Pharmacometrics & Systems Pharmacology ; 5 ; 516-531

Erscheinungsdatum:

01.10.2016

Format / Umfang:

16 pages

ISSN:

DOI:

https://doi.org/10.1002/psp4.12134

Medientyp:

Aufsatz (Zeitschrift)

Format:

Elektronische Ressource

Sprache:

Englisch

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