A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
https://orcid.org/0000-0001-9860-4141
Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH3) reduction of a nitrile bearing a CF3 group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.
Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
https://orcid.org/0000-0001-9860-4141
Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH3) reduction of a nitrile bearing a CF3 group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.
Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
https://orcid.org/0000-0001-9860-4141
Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH3) reduction of a nitrile bearing a CF3 group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.
Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
Taydakov, Ilya V. (author)
ACS Chemical Health & Safety ; 27 ; 235-239
2020-07-27
Article (Journal)
Electronic Resource
English
Growth of aluminum on Si using dimethyl-ethyl amine alane
| British Library Online Contents | 1999
Highlights: Safety Blogs, Alane Reduction, Postlockdown Process Safety Concerns, and More
| American Chemical Society | 2021
Kinetics of laser thermal decomposition of trimethylamine alane
| British Library Online Contents | 1995
Catalytic effect of Ti and Ni on dehydrogenation of AlH3: A first principles investigation
| British Library Online Contents | 2015
Synergistic effect of TiF3 on the dehydriding property of α-AlH3 nano-composite
| British Library Online Contents | 2019