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Uncertainty Representation in Health Risk Assessment of Contaminated Sites
Human health risk assessment is a complex process consisting of four main steps. (1) hazard identification; (2) exposure analysis; (3) toxicity assessment; and (4) risk characterization. At each of these steps, there are many types of uncertainty, which includes non random variables, subjectivity and vagueness in information as well as random variables such as body weight, inhalation rate, and the exposure periods. Uncertainties in risk assessment are categorized as qualitative or quantitative with conservative estimates being used for risk assessment. US EPA guidelines recommend the use of 95th percentile values for the calculation of reference dose. It has been shown that this may lead to an overestimation of the risk value (Burmaster and Anderson 1993). Though the methods can be justified to be protective of sensitive sub-populations, uncertainty is not completely represented. The objective of this paper is to investigate the different uncertainties that play a role in contaminated site risk assessment and the application of various theories that could be employed to reduce the overall uncertainty.
Uncertainty Representation in Health Risk Assessment of Contaminated Sites
Human health risk assessment is a complex process consisting of four main steps. (1) hazard identification; (2) exposure analysis; (3) toxicity assessment; and (4) risk characterization. At each of these steps, there are many types of uncertainty, which includes non random variables, subjectivity and vagueness in information as well as random variables such as body weight, inhalation rate, and the exposure periods. Uncertainties in risk assessment are categorized as qualitative or quantitative with conservative estimates being used for risk assessment. US EPA guidelines recommend the use of 95th percentile values for the calculation of reference dose. It has been shown that this may lead to an overestimation of the risk value (Burmaster and Anderson 1993). Though the methods can be justified to be protective of sensitive sub-populations, uncertainty is not completely represented. The objective of this paper is to investigate the different uncertainties that play a role in contaminated site risk assessment and the application of various theories that could be employed to reduce the overall uncertainty.
Uncertainty Representation in Health Risk Assessment of Contaminated Sites
Zhang, Kejiang (author) / Achari, Gopal (author) / Kluck, Cheryl (author)
GeoCongress 2008 ; 2008 ; New Orleans, Louisiana, United States
GeoCongress 2008 ; 926-933
2008-03-07
Conference paper
Electronic Resource
English
Uncertainty Representation in Health Risk Assessment of Contaminated Sites
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