A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Modelling physical resilience in ageing mice
Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Frailty is the result of an accumulation of deficits, which occurs with age and reduces the ability to respond to adverse events (physical resilience). Modelling frailty and physical resilience in mice is challenging for many reasons. There is no consensus on the precise definition of frailty and resilience in patients or on how best to measure it. This makes it difficult to evaluate available mouse models. In addition, the characterization of those models is poor. Here we review potential models of physical resilience, focusing on those where there is some evidence that the administration of acute stressors requires integrative responses involving multiple tissues and where aged mice showed a delayed recovery or a worse outcome then young mice in response to the stressor. These models include sepsis, trauma, drug- and radiation exposure, kidney and brain ischemia, exposure to noise, heat and cold shock. ; This article is based upon work from COST Action (BM1402: MouseAGE), supported by COST (European Cooperation in Science and Technology) and European Union Research and Innovation Program Horizon 2020 (GrantAgreement Number 730879). This work was supported by the Austrian Research Fund (FWF: P30623-B26), the Spanish MINECO (SAF2016-77703), the European Regional Development Fund, and the MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing. ; Peer reviewed
Modelling physical resilience in ageing mice
Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Frailty is the result of an accumulation of deficits, which occurs with age and reduces the ability to respond to adverse events (physical resilience). Modelling frailty and physical resilience in mice is challenging for many reasons. There is no consensus on the precise definition of frailty and resilience in patients or on how best to measure it. This makes it difficult to evaluate available mouse models. In addition, the characterization of those models is poor. Here we review potential models of physical resilience, focusing on those where there is some evidence that the administration of acute stressors requires integrative responses involving multiple tissues and where aged mice showed a delayed recovery or a worse outcome then young mice in response to the stressor. These models include sepsis, trauma, drug- and radiation exposure, kidney and brain ischemia, exposure to noise, heat and cold shock. ; This article is based upon work from COST Action (BM1402: MouseAGE), supported by COST (European Cooperation in Science and Technology) and European Union Research and Innovation Program Horizon 2020 (GrantAgreement Number 730879). This work was supported by the Austrian Research Fund (FWF: P30623-B26), the Spanish MINECO (SAF2016-77703), the European Regional Development Fund, and the MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing. ; Peer reviewed
Modelling physical resilience in ageing mice
Schosserer, Markus (author) / Banks, Gareth (author) / Dogan, Soner (author) / Dungel, Peter (author) / Fernandes, Adelaide (author) / Marolt Presen, Darja (author) / Matheu, Ander (author) / Osuchowski, Marcin (author) / Potter, Paul (author) / Sanfeliu, Coral (author)
2019-01-01
30290161
Article (Journal)
Electronic Resource
English
DDC:
690
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