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Cardiorespiratory responses to fine particles during ambient PM2.5 pollution waves: Findings from a randomized crossover trial in young healthy adults
Graphical abstract Display Omitted
Highlights Exploring the effects of PM2.5 pollution waves (PPWs) on cardiopulmonary health. A combination of naturally occurring PPWs and indoor air purification. PPWs affect oxidative stress, platelet activation and respiratory inflammation. Air purification could alleviate the cardiopulmonary effects caused by PPWs.
Abstract Background PM2.5 pollution waves (PPWs) are severe air pollution events with extremely high-level concentration of ambient PM2.5. PPWs, such as haze days, were suggested to be associated with increased cardiopulmonary mortality and morbidity. However, the biological mechanism response to ambient PM2.5 during PPWs is still unclear. Methods A randomized crossover trial was conducted on 29 healthy young adults. Repeated health measurements were performed before, during and after two typical PPWs under filtered and sham indoor air purification, with a washout interval of at least 2 weeks. Health parameters including blood pressure (BP), pulmonary function, fractional exhaled nitric oxide (FeNO) and circulating biomarkers which reflect platelet activation, blood coagulation and systematic oxidative stress were measured. Results Ambient PM2.5 levels elevated apparently during PPWs. Under sham purification, significant increase in FeNO and soluble P-selectin (sP-selectin) and decreases in pulmonary function were observed from pre-PPWs period to during-PPWs period. The changes in health biomarkers as mentioned above became attenuated and insignificant under filtered condition. For instance, sP-selectin increased by 12.0% (95% CI: 3.8%, 20.8%) during-PPWs periods compared with pre-PPWs periods under sham purification, while non-significant change was observed under filtered condition. Significant associations between time-weighted personal PM2.5 exposure and increased levels of health biomarkers including FeNO, sP-selectin, oxidized low-density lipoprotein (ox-LDL) and 8-isoprostane (8-isoPGF2α) were found. Conclusion PPWs could affect cardiopulmonary health through systematic oxidative stress, platelet activation and respiratory inflammation in healthy adults, and short-term indoor air purification could alleviate the adverse cardiopulmonary effects.
Cardiorespiratory responses to fine particles during ambient PM2.5 pollution waves: Findings from a randomized crossover trial in young healthy adults
Graphical abstract Display Omitted
Highlights Exploring the effects of PM2.5 pollution waves (PPWs) on cardiopulmonary health. A combination of naturally occurring PPWs and indoor air purification. PPWs affect oxidative stress, platelet activation and respiratory inflammation. Air purification could alleviate the cardiopulmonary effects caused by PPWs.
Abstract Background PM2.5 pollution waves (PPWs) are severe air pollution events with extremely high-level concentration of ambient PM2.5. PPWs, such as haze days, were suggested to be associated with increased cardiopulmonary mortality and morbidity. However, the biological mechanism response to ambient PM2.5 during PPWs is still unclear. Methods A randomized crossover trial was conducted on 29 healthy young adults. Repeated health measurements were performed before, during and after two typical PPWs under filtered and sham indoor air purification, with a washout interval of at least 2 weeks. Health parameters including blood pressure (BP), pulmonary function, fractional exhaled nitric oxide (FeNO) and circulating biomarkers which reflect platelet activation, blood coagulation and systematic oxidative stress were measured. Results Ambient PM2.5 levels elevated apparently during PPWs. Under sham purification, significant increase in FeNO and soluble P-selectin (sP-selectin) and decreases in pulmonary function were observed from pre-PPWs period to during-PPWs period. The changes in health biomarkers as mentioned above became attenuated and insignificant under filtered condition. For instance, sP-selectin increased by 12.0% (95% CI: 3.8%, 20.8%) during-PPWs periods compared with pre-PPWs periods under sham purification, while non-significant change was observed under filtered condition. Significant associations between time-weighted personal PM2.5 exposure and increased levels of health biomarkers including FeNO, sP-selectin, oxidized low-density lipoprotein (ox-LDL) and 8-isoprostane (8-isoPGF2α) were found. Conclusion PPWs could affect cardiopulmonary health through systematic oxidative stress, platelet activation and respiratory inflammation in healthy adults, and short-term indoor air purification could alleviate the adverse cardiopulmonary effects.
Cardiorespiratory responses to fine particles during ambient PM2.5 pollution waves: Findings from a randomized crossover trial in young healthy adults
Zhao, Yan (author) / Xue, Lijun (author) / Chen, Qiao (author) / Kou, Minghao (author) / Wang, Zemin (author) / Wu, Shaowei (author) / Huang, Jing (author) / Guo, Xinbiao (author)
2020-02-17
Article (Journal)
Electronic Resource
English
PM<inf>2.5</inf> pollution waves , Indoor purification , Oxidative stress , Platelet activation , Respiratory inflammation , 8-isoPGF2α , 8-isoprostane , ATS , American Thoracic Society , AQI , air quality index , BMI , body mass index , BP , blood pressure , CI , confidence interval , COPD , chronic obstructive pulmonary disease , DBP , diastolic blood pressure , EC-SOD , extracellular superoxide dismutase , ELISA , enzyme-linked immunosorbent assay , ERS , European Respiratory Society , FEF<inf>25-75%</inf> , forced expiratory flow between the 25th and 75th percentile of forced vital capacity , FeNO , fractional exhaled nitric oxide , FEV<inf>1</inf> , forced expiratory volume in one second , FVC , forced vital capacity , GPx1 , glutathione peroxidase 1 , HEPA , high-efficiency particulate air , IQR , interquartile range , MDA , malondialdehyde , ox-LDL , oxidized low-density lipoprotein , PEF , peak expiratory flow , PM<inf>2.5</inf> , particulate matter with an aerodynamic diameter ≤ 2.5 μm or fine particle , PPWs , ROS , reactive oxygen species , SBP , systolic blood pressure , SD , standard deviation , SE , standard error , sP-selectin , soluble P-selectin , vWF , von Willebrand factor , WHO , World Health Organization
| DOAJ | 2022
| Elsevier | 2022