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Preparation, characterization and application in controlled release of Ibuprofen-loaded Guar Gum/Montmorillonite Bionanocomposites
AbstractNeutral guar gum-montmorillonite and cationic guar gum-montmorillonite nanocomposites loaded with ibuprofen were prepared, and their ability to control in vitro release of the drug was presented. These materials exhibited a reduced initial burst release effect and sustained release of up to several hours in a pH 7.4 simulated intestinal fluid. Blank experiments suggested a nanocomposite-mediated action. Improved properties were demonstrated for two different clay minerals: Sodium Wyoming (SWy-2) montmorillonite from the Source Clay Repository and a Portuguese montmorillonite from the Benavila bentonite deposit. The prepared materials were based on abundant, low-cost, natural minerals and plant-extracted biopolymers, and were synthesized using a facile method, thus exhibiting a low environmental impact.
Graphical abstract
HighlightsGuar gum – montmorillonite nanocomposites loaded with Ibuprofen were synthesized.Natural Portuguese clay and commercial smectite were used.The nanocomposites exhibited a reduced Ibuprofen release rate at pH 7.4.Blank release experiments suggested a nanocomposite-induced action.
Preparation, characterization and application in controlled release of Ibuprofen-loaded Guar Gum/Montmorillonite Bionanocomposites
AbstractNeutral guar gum-montmorillonite and cationic guar gum-montmorillonite nanocomposites loaded with ibuprofen were prepared, and their ability to control in vitro release of the drug was presented. These materials exhibited a reduced initial burst release effect and sustained release of up to several hours in a pH 7.4 simulated intestinal fluid. Blank experiments suggested a nanocomposite-mediated action. Improved properties were demonstrated for two different clay minerals: Sodium Wyoming (SWy-2) montmorillonite from the Source Clay Repository and a Portuguese montmorillonite from the Benavila bentonite deposit. The prepared materials were based on abundant, low-cost, natural minerals and plant-extracted biopolymers, and were synthesized using a facile method, thus exhibiting a low environmental impact.
Graphical abstract
HighlightsGuar gum – montmorillonite nanocomposites loaded with Ibuprofen were synthesized.Natural Portuguese clay and commercial smectite were used.The nanocomposites exhibited a reduced Ibuprofen release rate at pH 7.4.Blank release experiments suggested a nanocomposite-induced action.
Preparation, characterization and application in controlled release of Ibuprofen-loaded Guar Gum/Montmorillonite Bionanocomposites
Dziadkowiec, Joanna (author) / Mansa, Rola (author) / Quintela, Ana (author) / Rocha, Fernando (author) / Detellier, Christian (author)
Applied Clay Science ; 135 ; 52-63
2016-09-03
12 pages
Article (Journal)
Electronic Resource
English
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