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Methods and systems for predicting misfolded protein epitopes
A method and system to identify an epitope unique to a misfolded form of a protein is provided. Sets of one or more amino acid residues are selected from a model representing the structure of the protein; the free energy of unfolding of each set is determined; and the epitope is identified from the sets having a total probability of unfolding above a minimum probability or a free energy of unfolding below a minimum energy. In other aspects, the invention provides for the use of epitopes identified by the epitope prediction methods, and related antibodies, to diagnose and treat disease and to screen samples for the presence of such epitopes.
Methods and systems for predicting misfolded protein epitopes
A method and system to identify an epitope unique to a misfolded form of a protein is provided. Sets of one or more amino acid residues are selected from a model representing the structure of the protein; the free energy of unfolding of each set is determined; and the epitope is identified from the sets having a total probability of unfolding above a minimum probability or a free energy of unfolding below a minimum energy. In other aspects, the invention provides for the use of epitopes identified by the epitope prediction methods, and related antibodies, to diagnose and treat disease and to screen samples for the presence of such epitopes.
Methods and systems for predicting misfolded protein epitopes
CASHMAN NEIL R (author) / PLOTKIN STEVEN S (author) / GUEST WILLIAM C (author)
2015-11-26
Patent
Electronic Resource
English
IPC:
C07K
PEPTIDES
,
Peptide
/
A61K
Zubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke
,
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
/
A61P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
,
Spezifische therapeutische Aktivität von chemischen Verbindungen oder medizinischen Zubereitungen
/
C04B
Kalk
,
LIME
/
G01N
Untersuchen oder Analysieren von Stoffen durch Bestimmen ihrer chemischen oder physikalischen Eigenschaften
,
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
/
G06F
ELECTRIC DIGITAL DATA PROCESSING
,
Elektrische digitale Datenverarbeitung
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