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3D printing machinable biological ceramic scaffold as well as preparation method and application thereof
The invention discloses a 3D printing machinable biological ceramic scaffold as well as a preparation method and application thereof. The 3D printing machinable biological ceramic scaffold is made of biological ceramic, has a three-dimensional porous structure and the porosity of 30%-70%, and is machinable. According to the method, micron-sized large-size ceramic powder is adopted for 3D printing, the particle size distribution of the ceramic powder is controlled within a narrow range, and a layer-by-layer curing mode is adopted for 3D printing, so that the prepared ceramic scaffold has certain mechanical strength while being machinable, it is guaranteed that a main body structure is not broken in the cutting process, and meanwhile, the space supporting effect in the repairing process is guaranteed. A complex and precise three-dimensional porous biological ceramic scaffold structure can be prepared through a 3D printing process, space is provided for ingrowth of cells and bone tissues, osteogenesis and vascularization are structurally facilitated, and regeneration and repair of bone defects can be promoted.
本发明公开了一种3D打印可切削生物陶瓷支架及其制备方法与应用。所述3D打印可切削生物陶瓷支架由生物陶瓷制成，具有三维多孔结构，孔隙率为30％～70％；具有可切削性能。本发明通过采用微米级的大尺寸陶瓷粉体进行3D打印，并将陶瓷粉的粒径分布控制在较窄的范围内，并采用逐层固化的方式进行3D打印，从而使制备的陶瓷支架在可切削的同时也具有一定的力学强度，保证切削过程中主体结构不发生碎裂，同时保证修复过程的空间支撑效果。本发明通过3D打印工艺可制备出复杂、精密的三维多孔生物陶瓷支架结构，为细胞和骨组织的长入提供空间，在结构上有利于成骨和血管化，可以促进骨缺损的再生修复。
3D printing machinable biological ceramic scaffold as well as preparation method and application thereof
The invention discloses a 3D printing machinable biological ceramic scaffold as well as a preparation method and application thereof. The 3D printing machinable biological ceramic scaffold is made of biological ceramic, has a three-dimensional porous structure and the porosity of 30%-70%, and is machinable. According to the method, micron-sized large-size ceramic powder is adopted for 3D printing, the particle size distribution of the ceramic powder is controlled within a narrow range, and a layer-by-layer curing mode is adopted for 3D printing, so that the prepared ceramic scaffold has certain mechanical strength while being machinable, it is guaranteed that a main body structure is not broken in the cutting process, and meanwhile, the space supporting effect in the repairing process is guaranteed. A complex and precise three-dimensional porous biological ceramic scaffold structure can be prepared through a 3D printing process, space is provided for ingrowth of cells and bone tissues, osteogenesis and vascularization are structurally facilitated, and regeneration and repair of bone defects can be promoted.
本发明公开了一种3D打印可切削生物陶瓷支架及其制备方法与应用。所述3D打印可切削生物陶瓷支架由生物陶瓷制成，具有三维多孔结构，孔隙率为30％～70％；具有可切削性能。本发明通过采用微米级的大尺寸陶瓷粉体进行3D打印，并将陶瓷粉的粒径分布控制在较窄的范围内，并采用逐层固化的方式进行3D打印，从而使制备的陶瓷支架在可切削的同时也具有一定的力学强度，保证切削过程中主体结构不发生碎裂，同时保证修复过程的空间支撑效果。本发明通过3D打印工艺可制备出复杂、精密的三维多孔生物陶瓷支架结构，为细胞和骨组织的长入提供空间，在结构上有利于成骨和血管化，可以促进骨缺损的再生修复。
3D printing machinable biological ceramic scaffold as well as preparation method and application thereof
一种3D打印可切削生物陶瓷支架及其制备方法与应用
CHEN ZHENHUA (author) / ZHANG YING (author) / CHEN YANG (author) / XU XIU (author) / HUANG LING (author) / WANG BIN (author) / LIU QIXING (author) / ZHANG DONGGANG (author)
2021-06-15
Patent
Electronic Resource
Chinese
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