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Multi-cell patterned biological ceramic scaffold as well as preparation method and application thereof
The invention discloses a multicellular patterned biological ceramic scaffold as well as a preparation method and application thereof. The multi-cell patterned biological ceramic scaffold comprises a multi-channel honeycomb biological ceramic scaffold carrier and multiple types of cells adaptively loaded into channels of the multi-channel honeycomb biological ceramic scaffold carrier, and the cells distributed in the channels form a multi-cell arrangement pattern to construct a bionic in-vivo multi-cell microenvironment. The multicellular patterned biological ceramic scaffold can effectively regulate and control interaction among multicellular lines and construct a microenvironment beneficial to tissue regeneration by controlling spatial position distribution of multicellular lines on the scaffold, so that the osteogenesis performance of the biological ceramic scaffold is improved, the repair speed and quality of bone defects are improved, and the application prospect is wide. Wide application prospects are realized in the aspect of biomedical application.
本发明公开一种多细胞图案化生物陶瓷支架及其制备方法和应用。所述多细胞图案化的生物陶瓷支架包括多通道蜂窝状生物陶瓷支架载体和适应性装载到多通道蜂窝状生物陶瓷支架载体的通道的多种类型的细胞，所述通道中分布的细胞形成多细胞排布图案而构建仿生的体内多细胞微环境。所述多细胞图案化的生物陶瓷支架可通过操纵多细胞在支架上的空间位置分布，有效调控多细胞系之间相互作用，构建有利于组织再生的微环境，进而改善生物陶瓷支架的成骨性能，提高了骨缺损的修复速度和质量，在生物医学应用方面有广阔的应用前景。
Multi-cell patterned biological ceramic scaffold as well as preparation method and application thereof
The invention discloses a multicellular patterned biological ceramic scaffold as well as a preparation method and application thereof. The multi-cell patterned biological ceramic scaffold comprises a multi-channel honeycomb biological ceramic scaffold carrier and multiple types of cells adaptively loaded into channels of the multi-channel honeycomb biological ceramic scaffold carrier, and the cells distributed in the channels form a multi-cell arrangement pattern to construct a bionic in-vivo multi-cell microenvironment. The multicellular patterned biological ceramic scaffold can effectively regulate and control interaction among multicellular lines and construct a microenvironment beneficial to tissue regeneration by controlling spatial position distribution of multicellular lines on the scaffold, so that the osteogenesis performance of the biological ceramic scaffold is improved, the repair speed and quality of bone defects are improved, and the application prospect is wide. Wide application prospects are realized in the aspect of biomedical application.
本发明公开一种多细胞图案化生物陶瓷支架及其制备方法和应用。所述多细胞图案化的生物陶瓷支架包括多通道蜂窝状生物陶瓷支架载体和适应性装载到多通道蜂窝状生物陶瓷支架载体的通道的多种类型的细胞，所述通道中分布的细胞形成多细胞排布图案而构建仿生的体内多细胞微环境。所述多细胞图案化的生物陶瓷支架可通过操纵多细胞在支架上的空间位置分布，有效调控多细胞系之间相互作用，构建有利于组织再生的微环境，进而改善生物陶瓷支架的成骨性能，提高了骨缺损的修复速度和质量，在生物医学应用方面有广阔的应用前景。
Multi-cell patterned biological ceramic scaffold as well as preparation method and application thereof
一种多细胞图案化生物陶瓷支架及其制备方法和应用
WU CHENGTIE (author) / ZHANG BINGJUN (author)
2022-04-29
Patent
Electronic Resource
Chinese
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