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A platform for research: civil engineering, architecture and urbanism
Bone tissue repair material and preparation method of bone tissue engineering scaffold
The invention relates to the technical field of regenerative medicine, and discloses a bone tissue repair material and a preparation method of a bone tissue engineering scaffold. The bone tissue repair material comprises the following components in parts by weight: 10-40 parts of an oil-soluble high polymer material, 10-50 parts of biological ceramic powder, 50-100 parts of an oily solvent, 0.1-1 part of a water-soluble bone tissue repair medicine, 2-30 parts of water, more than 0 part and not more than 10 parts of seed cells and 50-100 parts of a culture medium. According to the bone tissue repair material disclosed by the invention, the oil-soluble high polymer material and the biological ceramic powder are matched with each other to form a base material of a bone tissue engineering scaffold, so that enough structural/mechanical properties are provided for the printed bone tissue engineering scaffold, and a personalized bone tissue engineering scaffold can be prepared by utilizing 3D printing equipment. Osteoblast osteogenic differentiation is promoted through the effect of the water-soluble bone tissue repair medicine, so that bone tissue enables bone cells to be differentiated to form a perfect bone tissue structure on the basis of a bone tissue engineering scaffold.
本发明涉及再生医学技术领域，公开了一种骨组织修复材料及骨组织工程支架的制备方法。所述骨组织修复材料，按照重量份数计，包括以下组分：油溶性高分子材料10～40份，生物陶瓷粉体10～50份，油性溶剂50～100份，水溶性骨组织修复药物0.1～1份，水2～30份，种子细胞大于0份且不大于10份，以及培养基50～100份。本发明的骨组织修复材料通过油溶性高分子材料和生物陶瓷粉体的相互配合，形成骨组织工程支架的基材，以便为打印的骨组织工程支架提供足够的结构/力学性能，利用3D打印设备即可制备个性化的骨组织工程支架；通过水溶性骨组织修复药物的作用促进成骨细胞成骨分化，使得骨组织在骨组织工程支架的基础上使骨细胞分化形成完善的骨组织结构。
Bone tissue repair material and preparation method of bone tissue engineering scaffold
The invention relates to the technical field of regenerative medicine, and discloses a bone tissue repair material and a preparation method of a bone tissue engineering scaffold. The bone tissue repair material comprises the following components in parts by weight: 10-40 parts of an oil-soluble high polymer material, 10-50 parts of biological ceramic powder, 50-100 parts of an oily solvent, 0.1-1 part of a water-soluble bone tissue repair medicine, 2-30 parts of water, more than 0 part and not more than 10 parts of seed cells and 50-100 parts of a culture medium. According to the bone tissue repair material disclosed by the invention, the oil-soluble high polymer material and the biological ceramic powder are matched with each other to form a base material of a bone tissue engineering scaffold, so that enough structural/mechanical properties are provided for the printed bone tissue engineering scaffold, and a personalized bone tissue engineering scaffold can be prepared by utilizing 3D printing equipment. Osteoblast osteogenic differentiation is promoted through the effect of the water-soluble bone tissue repair medicine, so that bone tissue enables bone cells to be differentiated to form a perfect bone tissue structure on the basis of a bone tissue engineering scaffold.
本发明涉及再生医学技术领域，公开了一种骨组织修复材料及骨组织工程支架的制备方法。所述骨组织修复材料，按照重量份数计，包括以下组分：油溶性高分子材料10～40份，生物陶瓷粉体10～50份，油性溶剂50～100份，水溶性骨组织修复药物0.1～1份，水2～30份，种子细胞大于0份且不大于10份，以及培养基50～100份。本发明的骨组织修复材料通过油溶性高分子材料和生物陶瓷粉体的相互配合，形成骨组织工程支架的基材，以便为打印的骨组织工程支架提供足够的结构/力学性能，利用3D打印设备即可制备个性化的骨组织工程支架；通过水溶性骨组织修复药物的作用促进成骨细胞成骨分化，使得骨组织在骨组织工程支架的基础上使骨细胞分化形成完善的骨组织结构。
Bone tissue repair material and preparation method of bone tissue engineering scaffold
骨组织修复材料及骨组织工程支架的制备方法
LIU JIA (author) / TANG YUJIN (author) / ZHENG CHUANCHUAN (author) / LI KAI (author) / WANG CHONG (author) / WANG LIQIANG (author) / YANG CHENGLIANG (author) / LI YE (author) / HUANG KE (author) / LAN CHANGGONG (author)
2021-07-27
Patent
Electronic Resource
Chinese
IPC:
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
/
C04B
Kalk
,
LIME
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