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Ion-doped biphase calcium phosphate composite ceramic scaffold with three-dimensional communicated hierarchical pore structure as well as preparation method and application of ion-doped biphase calcium phosphate composite ceramic scaffold
The invention discloses an ion-doped biphase calcium phosphate composite ceramic scaffold with a three-dimensional communicated hierarchical pore structure as well as a preparation method and application of the ion-doped biphase calcium phosphate composite ceramic scaffold. The preparation method comprises the following steps: preparing Zn ion-doped biphase calcium phosphate by adopting a chemical coprecipitation method and calcining, then compounding three active ion-doped biphase calcium phosphate, namely Si, Mg and Sr, prepared by the same method according to a certain proportion, carrying out chemical composition modification on two different active ions, adding methylcellulose and polyvinyl alcohol, and blending into printing slurry. A hierarchical pore structure with three-dimensional communicated macropores and micro-nano-scale micropores compounded is constructed by 3D printing of a 3D printing technology and is subjected to structural modification, and the calcium phosphate ceramic scaffold which is synergistically modified plays a role in promoting osteogenesis. The biphasic calcium phosphate ceramic scaffold has the characteristics of simple preparation process, uniform ion component distribution and good mechanical and biological properties, and has important significance in expanding the clinical application of the biphasic calcium phosphate ceramic scaffold in non-bearing bone defect repair.
本发明公开了一种具有三维连通多级孔结构的离子掺杂双相磷酸钙复合陶瓷支架及其制备方法和应用。本发明采用了化学共沉淀法并煅烧制备Zn离子掺杂双相磷酸钙，再分别按一定比例复合以同样方法制备的Si、Mg、Sr三种活性离子掺杂双相磷酸钙进行两种不同活性离子的化学组成改性，加入甲基纤维素和聚乙烯醇调和成打印浆料，利用3D打印技术3D打印构建具有三维连通大孔和微纳米级微孔复合的多级孔结构进行结构改性，协同改性的磷酸钙陶瓷支架起促成骨作用。具有制备工艺简单、离子成分分布均匀，力学和生物学性能良好的特点，对拓展双相磷酸钙陶瓷支架在非承重骨缺损修复的临床应用具有重要意义。
Ion-doped biphase calcium phosphate composite ceramic scaffold with three-dimensional communicated hierarchical pore structure as well as preparation method and application of ion-doped biphase calcium phosphate composite ceramic scaffold
The invention discloses an ion-doped biphase calcium phosphate composite ceramic scaffold with a three-dimensional communicated hierarchical pore structure as well as a preparation method and application of the ion-doped biphase calcium phosphate composite ceramic scaffold. The preparation method comprises the following steps: preparing Zn ion-doped biphase calcium phosphate by adopting a chemical coprecipitation method and calcining, then compounding three active ion-doped biphase calcium phosphate, namely Si, Mg and Sr, prepared by the same method according to a certain proportion, carrying out chemical composition modification on two different active ions, adding methylcellulose and polyvinyl alcohol, and blending into printing slurry. A hierarchical pore structure with three-dimensional communicated macropores and micro-nano-scale micropores compounded is constructed by 3D printing of a 3D printing technology and is subjected to structural modification, and the calcium phosphate ceramic scaffold which is synergistically modified plays a role in promoting osteogenesis. The biphasic calcium phosphate ceramic scaffold has the characteristics of simple preparation process, uniform ion component distribution and good mechanical and biological properties, and has important significance in expanding the clinical application of the biphasic calcium phosphate ceramic scaffold in non-bearing bone defect repair.
本发明公开了一种具有三维连通多级孔结构的离子掺杂双相磷酸钙复合陶瓷支架及其制备方法和应用。本发明采用了化学共沉淀法并煅烧制备Zn离子掺杂双相磷酸钙，再分别按一定比例复合以同样方法制备的Si、Mg、Sr三种活性离子掺杂双相磷酸钙进行两种不同活性离子的化学组成改性，加入甲基纤维素和聚乙烯醇调和成打印浆料，利用3D打印技术3D打印构建具有三维连通大孔和微纳米级微孔复合的多级孔结构进行结构改性，协同改性的磷酸钙陶瓷支架起促成骨作用。具有制备工艺简单、离子成分分布均匀，力学和生物学性能良好的特点，对拓展双相磷酸钙陶瓷支架在非承重骨缺损修复的临床应用具有重要意义。
Ion-doped biphase calcium phosphate composite ceramic scaffold with three-dimensional communicated hierarchical pore structure as well as preparation method and application of ion-doped biphase calcium phosphate composite ceramic scaffold
一种具有三维连通多级孔结构的离子掺杂双相磷酸钙复合陶瓷支架及其制备方法和应用
YE JIANDONG (author) / YUE TING (author)
2023-07-14
Patent
Electronic Resource
Chinese
IPC:
C04B
Kalk
,
LIME
/
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
Self-Setting Biphase Porous Calcium Phosphate Cement
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