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Active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone and preparation method thereof
The invention discloses an active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone and a preparation method thereof. Active ion-doped weak crystal calcium-deficient hydroxyapatite powder is prepared by combining a chemical precipitation method with low-temperature sintering, then active ion-doped weak crystal calcium-deficient hydroxyapatite ceramic microspheres are prepared by adopting an extrusion spheronization method, and then the active ion-doped weak crystal calcium-deficient hydroxyapatite ceramic microspheres are obtained after isostatic cool pressing, drying, low-temperature sintering and screening. The active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone is obtained. The preparation process is relatively simple, the prepared weakly-crystallized calcium-deficient hydroxyapatite ceramic belongs to nano biological ceramic, shows better biological activity and can be closer to the composition of an inorganic mineral phase of natural bone tissue, and the osteogenic activity and the vasogenic activity of the material are effectively improved through active ion doping, so that the osteogenic activity and the vasogenic activity of the material are improved, and the osteogenic activity and the vasogenic activity of the material are improved. The method has important significance in broadening clinical application of the weakly-crystallized calcium-deficient hydroxyapatite in the field of bone defect filling and repairing.
本发明公开了一种活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球人工骨及其制备方法。本发明是通过化学沉淀法结合低温烧结制备出活性离子掺杂的弱结晶缺钙羟基磷灰石粉体，然后采用挤出滚圆法制备得到活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球，然后经过冷等静压、干燥、低温烧结以及筛分后，就得到活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球人工骨。本发明制备工艺较简单，制备出的弱结晶缺钙羟基磷灰石陶瓷属于纳米生物陶瓷，表现出更好的生物活性，能够更加接近于天然骨组织的无机矿物相的组成，通过活性离子掺杂有效地提高了材料的成骨活性以及成血管活性，对于拓宽弱结晶缺钙羟基磷灰石在骨缺损填充修复领域的临床应用具有重要意义。
Active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone and preparation method thereof
The invention discloses an active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone and a preparation method thereof. Active ion-doped weak crystal calcium-deficient hydroxyapatite powder is prepared by combining a chemical precipitation method with low-temperature sintering, then active ion-doped weak crystal calcium-deficient hydroxyapatite ceramic microspheres are prepared by adopting an extrusion spheronization method, and then the active ion-doped weak crystal calcium-deficient hydroxyapatite ceramic microspheres are obtained after isostatic cool pressing, drying, low-temperature sintering and screening. The active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone is obtained. The preparation process is relatively simple, the prepared weakly-crystallized calcium-deficient hydroxyapatite ceramic belongs to nano biological ceramic, shows better biological activity and can be closer to the composition of an inorganic mineral phase of natural bone tissue, and the osteogenic activity and the vasogenic activity of the material are effectively improved through active ion doping, so that the osteogenic activity and the vasogenic activity of the material are improved, and the osteogenic activity and the vasogenic activity of the material are improved. The method has important significance in broadening clinical application of the weakly-crystallized calcium-deficient hydroxyapatite in the field of bone defect filling and repairing.
本发明公开了一种活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球人工骨及其制备方法。本发明是通过化学沉淀法结合低温烧结制备出活性离子掺杂的弱结晶缺钙羟基磷灰石粉体，然后采用挤出滚圆法制备得到活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球，然后经过冷等静压、干燥、低温烧结以及筛分后，就得到活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球人工骨。本发明制备工艺较简单，制备出的弱结晶缺钙羟基磷灰石陶瓷属于纳米生物陶瓷，表现出更好的生物活性，能够更加接近于天然骨组织的无机矿物相的组成，通过活性离子掺杂有效地提高了材料的成骨活性以及成血管活性，对于拓宽弱结晶缺钙羟基磷灰石在骨缺损填充修复领域的临床应用具有重要意义。
Active ion doped weak crystal calcium-deficient hydroxyapatite ceramic microsphere artificial bone and preparation method thereof
一种活性离子掺杂弱结晶缺钙羟基磷灰石陶瓷微球人工骨及其制备方法
YE JIANDONG (author) / ZHANG JIA (author)
2023-07-21
Patent
Electronic Resource
Chinese
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