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Semiquinone glucoside derivative provides protection against γ‐radiation by modulation of immune response in murine model
Present study was undertaken to evaluate radioprotective and immunomodulatory activities of a novel semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM‐1 in C 57 BL/6 mice. Whole body survival study was performed to evaluate in vivo radioprotective efficacy of SQGD. To observe effect of SQGD on immunostimulation, Circulatory cytokine (i.e., interleukin‐2 (IL‐2), IFN‐γ, IL‐10, granulocyte colony stimulating factor (G‐CSF), granulocyte macrophage colony stimulating factor (GM‐CSF), and macrophage colony stimulating factor (M‐CSF) expression was analyzed in serum of irradiated and SQGD treated mice at different time intervals using ELISA assay. Results of the present investigation indicated that SQGD pre‐treatment (‐2 h) to lethally irradiated mice provide ∼83% whole body survival compared with irradiated mice where no survival was observed at 30 th post irradiation day. Significant ( p < 0.05) induction in IL‐2 and IFN‐γ expression was observed at all tested time intervals with SQGD pre‐treated irradiated mice as compared with irradiated mice alone. However, sharp increase in IL‐10 expression was observed in irradiated mice which were found to be subsidized in irradiated mice pre‐treated with SQGD. Similarly, significant ( p < 0.05%) induction in G‐CSF, M‐CSF and GM‐CSF expression was observed in irradiated mice treated with SQGD as compared with irradiated control mice at tested time intervals. In conclusion, SQGD pre‐treatment to irradiated mice enhanced expression of IL‐12 and IFN‐γ while down‐regulated IL‐10 expression and thus modulates cytoprotective pro‐inflammatory TH 1 type immune response in irradiated mice. Further, SQGD pre‐treatment to irradiated mice accelerate G‐CSF, GM‐CSF and M‐CSF expression suggesting improved haematopoiesis and enhanced cellular immune response in immuno‐compromised irradiated mice that may contribute to in vivo radiation protection. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 478–488, 2016.
Semiquinone glucoside derivative provides protection against γ‐radiation by modulation of immune response in murine model
Present study was undertaken to evaluate radioprotective and immunomodulatory activities of a novel semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM‐1 in C 57 BL/6 mice. Whole body survival study was performed to evaluate in vivo radioprotective efficacy of SQGD. To observe effect of SQGD on immunostimulation, Circulatory cytokine (i.e., interleukin‐2 (IL‐2), IFN‐γ, IL‐10, granulocyte colony stimulating factor (G‐CSF), granulocyte macrophage colony stimulating factor (GM‐CSF), and macrophage colony stimulating factor (M‐CSF) expression was analyzed in serum of irradiated and SQGD treated mice at different time intervals using ELISA assay. Results of the present investigation indicated that SQGD pre‐treatment (‐2 h) to lethally irradiated mice provide ∼83% whole body survival compared with irradiated mice where no survival was observed at 30 th post irradiation day. Significant ( p < 0.05) induction in IL‐2 and IFN‐γ expression was observed at all tested time intervals with SQGD pre‐treated irradiated mice as compared with irradiated mice alone. However, sharp increase in IL‐10 expression was observed in irradiated mice which were found to be subsidized in irradiated mice pre‐treated with SQGD. Similarly, significant ( p < 0.05%) induction in G‐CSF, M‐CSF and GM‐CSF expression was observed in irradiated mice treated with SQGD as compared with irradiated control mice at tested time intervals. In conclusion, SQGD pre‐treatment to irradiated mice enhanced expression of IL‐12 and IFN‐γ while down‐regulated IL‐10 expression and thus modulates cytoprotective pro‐inflammatory TH 1 type immune response in irradiated mice. Further, SQGD pre‐treatment to irradiated mice accelerate G‐CSF, GM‐CSF and M‐CSF expression suggesting improved haematopoiesis and enhanced cellular immune response in immuno‐compromised irradiated mice that may contribute to in vivo radiation protection. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 478–488, 2016.
Semiquinone glucoside derivative provides protection against γ‐radiation by modulation of immune response in murine model
Mishra, S (author) / Patel, D. D / Bansal, D. D / Kumar, R
2016
Article (Journal)
English
Semiquinone cation adsorption on montmorillonite as function of surface acidity
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