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Visualizing Structures of Biological Macromolecules Through Indirect Imaging with Small-Angle Neutron Scattering and Modeling
Abstract The molecular machinery of living organisms is built of systems whose length scales range from nanometers to microns. While neutron imaging is a powerful tool for studying macroscopic systems, neutron optics is not capable of effectively resolving these macromolecular systems. Small-angle neutron scattering when combined with modeling and contrast variation methods enables indirect imaging for visualization of structure and function over these length scales. A brief overview of small-angle neutron scattering with contrast variation is presented with a description of available modeling methods. Applications of the methods are also presented to provide a survey of the wide variety of systems that are suitable for study.
Visualizing Structures of Biological Macromolecules Through Indirect Imaging with Small-Angle Neutron Scattering and Modeling
Abstract The molecular machinery of living organisms is built of systems whose length scales range from nanometers to microns. While neutron imaging is a powerful tool for studying macroscopic systems, neutron optics is not capable of effectively resolving these macromolecular systems. Small-angle neutron scattering when combined with modeling and contrast variation methods enables indirect imaging for visualization of structure and function over these length scales. A brief overview of small-angle neutron scattering with contrast variation is presented with a description of available modeling methods. Applications of the methods are also presented to provide a survey of the wide variety of systems that are suitable for study.
Visualizing Structures of Biological Macromolecules Through Indirect Imaging with Small-Angle Neutron Scattering and Modeling
Heller, W. T. (author) / Baker, G. A. (author)
2009-01-01
16 pages
Article/Chapter (Book)
Electronic Resource
English
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