A platform for research: civil engineering, architecture and urbanism
A platform for research: civil engineering, architecture and urbanism
Risk of lung cancer and residental radon in China: pooled results of two studies
Studies of radon-exposed underground miners predict that residential radon is the second leading cause of lung cancer mortality; however, case-control studies of residential radon have not provided unambiguous evidence of an association. Owing to small expected risks from residential radon and uncertainties in dosimetry, large studies or pooling of multiple studies are needed to fully evaluate effects. The authors pooled data from 2 case-control studies of residential radon representing 2 large radon studies conducted in China. The studies included 1050 lung cancer cases and 1996 controls. In the pooled data, odds ratios (OR) increased significantly with greater radon concentration. Based on a linear model, the OR with 95 % confidence intervals (CI) at 100 Becquerel/cubic-meter (Bq/m3) was 1.13 (1.01 - 1.36). For subjects resident in the current home for 30 years or more, the OR at 100 Bq/m3 was 1.32 (1.07 - 1.91). Results across studies were consistent with homogeneity. Estimates of ORs were similar to extrapolations from miner data and consistent with published residential radon studies in North American and Europe, suggesting long-term radon exposure at concentrations found in many homes increases lung cancer risk.
Risk of lung cancer and residental radon in China: pooled results of two studies
Studies of radon-exposed underground miners predict that residential radon is the second leading cause of lung cancer mortality; however, case-control studies of residential radon have not provided unambiguous evidence of an association. Owing to small expected risks from residential radon and uncertainties in dosimetry, large studies or pooling of multiple studies are needed to fully evaluate effects. The authors pooled data from 2 case-control studies of residential radon representing 2 large radon studies conducted in China. The studies included 1050 lung cancer cases and 1996 controls. In the pooled data, odds ratios (OR) increased significantly with greater radon concentration. Based on a linear model, the OR with 95 % confidence intervals (CI) at 100 Becquerel/cubic-meter (Bq/m3) was 1.13 (1.01 - 1.36). For subjects resident in the current home for 30 years or more, the OR at 100 Bq/m3 was 1.32 (1.07 - 1.91). Results across studies were consistent with homogeneity. Estimates of ORs were similar to extrapolations from miner data and consistent with published residential radon studies in North American and Europe, suggesting long-term radon exposure at concentrations found in many homes increases lung cancer risk.
Risk of lung cancer and residental radon in China: pooled results of two studies
Zusammenhang zwischen dem Risiko für Lungenkrebs und der Radonbelastung von Wohngebäuden in China: Gepoolte Ergebnisse zweier Studien
Lubin, J.H. (author) / Wang, Z.Y. (author) / Boice, J.D. (author) / Xu, Z.Y. (author) / Blot, W.J. (author) / Wang, L.D. (author) / Kleinerman, R.A. (author)
2004
11 Seiten, 1 Bild, 4 Tabellen, 35 Quellen
Conference paper
English
Lunge , Tumor , Gesundheitsrisiko , China , Radon , Strahlenbelastung , Wohngebäude , Lungenkrebs
Pooled analysis of two German studies on the lung cancer risk by radon in homes
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