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Method and device for evaluating tumor mutation load detection performance of NGS kit
The invention discloses a method and a device for evaluating tumor mutation load detection performance of an NGS kit, and relates to the field of signal analysis. According to the method, a TMB reference product and a real sample are adopted to form a set of standard data set with high confidence. On this basis, according to a set evaluation process and method, the construction of a TMB evaluation system is realized, and the analysis of the variation detection accuracy of the NGS kit and the TMB detection evaluation can be carried out based on a reference and a clinical sample. The evaluation method can meet analysis of variation detection accuracy of an NGS detection kit widely available in the market and TMB detection evaluation, and can provide reliable and accurate tumor large Panel detection for patients.
本发明公开了一种NGS试剂盒肿瘤突变负荷检测性能的评估方法及装置，涉及生信分析领域。本发明通过采用TMB参考品与真实样品，形成了一套具有高置信度的标准数据集的方法。在此基础上，按照设定的评估流程及方法，实现了TMB评估体系的构建，基于参考品和临床样品可以进行NGS试剂盒的变异探测准确度的分析与TMB检测评估。该评估方法可以满足市面上广泛的NGS检测试剂盒的变异探测准确度的分析与TMB检测评估，可以为患者提供一个可靠准确的肿瘤大Panel检测。
Method and device for evaluating tumor mutation load detection performance of NGS kit
The invention discloses a method and a device for evaluating tumor mutation load detection performance of an NGS kit, and relates to the field of signal analysis. According to the method, a TMB reference product and a real sample are adopted to form a set of standard data set with high confidence. On this basis, according to a set evaluation process and method, the construction of a TMB evaluation system is realized, and the analysis of the variation detection accuracy of the NGS kit and the TMB detection evaluation can be carried out based on a reference and a clinical sample. The evaluation method can meet analysis of variation detection accuracy of an NGS detection kit widely available in the market and TMB detection evaluation, and can provide reliable and accurate tumor large Panel detection for patients.
本发明公开了一种NGS试剂盒肿瘤突变负荷检测性能的评估方法及装置，涉及生信分析领域。本发明通过采用TMB参考品与真实样品，形成了一套具有高置信度的标准数据集的方法。在此基础上，按照设定的评估流程及方法，实现了TMB评估体系的构建，基于参考品和临床样品可以进行NGS试剂盒的变异探测准确度的分析与TMB检测评估。该评估方法可以满足市面上广泛的NGS检测试剂盒的变异探测准确度的分析与TMB检测评估，可以为患者提供一个可靠准确的肿瘤大Panel检测。
Method and device for evaluating tumor mutation load detection performance of NGS kit
一种NGS试剂盒肿瘤突变负荷检测性能的评估方法及装置
YING JIANMING (author) / ZHANG FANSHUANG (author) / LI WENBIN (author) / LING SHAOPING (author) / HAO LINGTONG (author) / LI XINZHENG (author)
2023-09-15
Patent
Electronic Resource
Chinese
IPC:
G16B
/
G16H
Medizinische Informatik, d.h. Informations- und Kommunikationstechnik [IKT] besonders ausgebildet für die Handhabung oder Verarbeitung medizinischer oder auf das Gesundheitswesen bezogener Daten
,
HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA